Abstract
Sepsis pathobiology is complex. Heterogeneity refers to the clinical and biological
variation within sepsis cohorts. Sepsis subtypes refer to subpopulations within sepsis
cohorts derived based on these observable variations and latent features. The overarching
goal of such endeavors is to enable precision immunomodulation. However, we are yet
to identify immune endotypes of sepsis to achieve this goal. The sepsis subtyping
field is just starting to take shape. The current subtypes in the literature do not
have a core set of shared features between studies. Thus, in this narrative review,
we reason that there is a need to a priori state the purpose of sepsis subtyping and minimum set of features that would be required
to achieve the goal of precision immunomodulation for future sepsis.
Keywords
sepsis - phenotypes - endotypes - infectious disease - critical care - subtypes -
precision medicine
