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Semin Respir Crit Care Med
DOI: 10.1055/s-0044-1782612
Review Article

Pleural Diseases in Connective Tissue Diseases

Hui Guo
1   Department of Respiratory and Sleep Medicine, The Alfred Hospital, Melbourne, VIC, Australia
,
Beenish Iqbal
2   Oxford Respiratory Trials Unit, Oxford Centre for Respiratory Disease, Oxford University Hospital, Oxford Centre for Respiratory Medicine, Churchill Hospital, NHS Trust, Oxford, United Kingdom
,
Najib M. Rahman
2   Oxford Respiratory Trials Unit, Oxford Centre for Respiratory Disease, Oxford University Hospital, Oxford Centre for Respiratory Medicine, Churchill Hospital, NHS Trust, Oxford, United Kingdom
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Abstract

Connective tissue diseases (CTD) are heterogeneous, immune-mediated inflammatory disorders often presenting with multiorgan involvement. With the advent of high-resolution computed tomography, CTD-related pleuritis—pleural thickening and effusion—is now increasingly recognized early in the disease trajectory. The natural history of CTD-related pleural effusions varies from spontaneous resolution to progressive fibrothorax with ventilatory impairment. Treatment of the underlying CTD is necessary to manage the pleural disease. Depending on the degree of symptom burden and physiological insult, specific treatment of pleural disease can include monitoring, repeated aspirations, systemic anti-inflammatory medication, and surgical decortication.

Keywords

connective tissue disease - collagen vascular disease - pleural disease - pleuritis - pleural effusion - pleural thickening - pneumothorax


Publication History

Article published online:
28 March 2024

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