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Synfacts 2024; 20(08): 0805
DOI: 10.1055/s-0043-1775221
Synthesis of Materials and Unnatural Products

Enantioselective Synthesis of Molecular Nanographene

Authors

    Contributor(s):

  • Dahui Zhao

  • Zepeng Lu

Buendía M, Fernández-García JM, Perles J, Filippone S, *, Martín N. * Universidad Complutense de Madrid, Spain
Enantioselective Synthesis of a Two-Fold Inherently Chiral Molecular Nanographene.

Nat. Synth. 2024;
3: 545-553
DOI: 10.1038/s44160-024-00484-x
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Key words

chiral nanographenes - chiral center - axial chirality - helicity

Significance

Enantioselective syntheses of a pair of all-carbon nanographene molecules, featuring central, axial, and helical, three types of chiral elements, are achieved.


 

Comment

The key step is the enantioselective double substitution of two OH groups at the chiral benzylic carbons by the aromatic nucleophiles. The resultant asymmetric stereo-configuration biases the helical chirality subsequently appearing in the Scholl reaction.


 

 

Publication History

Article published online:
25 July 2024

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