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Synfacts 2024; 20(10): 1115
DOI: 10.1055/s-0043-1775071
DOI: 10.1055/s-0043-1775071
Peptide Chemistry
Peptide Synthesis Using Unprotected Amino Acids with N-(Z-α-Aminoacyl)benzotriazoles
Katritzky AR,
*,
Suzuki K,
Singh SK.
University of Florida, Gainesville, USA
Highly Diastereoselective Peptide Chain Extensions of Unprotected Amino Acids with N-(Z-α-Aminoacyl)benzotriazoles.
Synthesis 2004; 2645-2652
DOI: 10.1055/s-2004-831255
Highly Diastereoselective Peptide Chain Extensions of Unprotected Amino Acids with N-(Z-α-Aminoacyl)benzotriazoles.
Synthesis 2004; 2645-2652
DOI: 10.1055/s-2004-831255
Significance
Development of practically handy and cost-effective methods for peptide synthesis is a highly demanding area of organic synthesis. In this study, the authors developed an elegant method for the synthesis of peptides by using unprotected amino acids with N-(Z-α-aminoacyl)benzotriazoles.
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Comment
A series of peptides were prepared by coupling between unprotected amino acids with N-(Z-α-aminoacyl)benzotriazoles. This method is practically simple and the reaction proceeded with minimum epimerization under mild reaction conditions.
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Publication History
Article published online:
13 September 2024
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