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Synfacts 2024; 20(09): 0931
DOI: 10.1055/s-0043-1775024
DOI: 10.1055/s-0043-1775024
Metals in Synthesis
Synthesis of Oximes by Nickel-Catalyzed Coupling of Nitrates with Organohalides
Padmanaban S,
Chun J,
Lee Y,
Cho K.-B,
*,
Choi J,
*,
Lee Y.
*
Jeonbuk National University, Jeonju, Chonnam National University, Gwangju and Seoul
National University, Republic of Korea
Nitrate Upcycling Mediated by Organonickel Catalysis.
Angew. Chem. Int. Ed. 2024; e202408457
DOI: 10.1002/anie.202408457
Nitrate Upcycling Mediated by Organonickel Catalysis.
Angew. Chem. Int. Ed. 2024; e202408457
DOI: 10.1002/anie.202408457
Significance
A nickel-catalyzed protocol for the selective coupling of nitrate salts with organohalides to form oximes is disclosed. This method represents a new strategy for upcycling the environmental pollutant nitrate into synthetically valuable chemicals.
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Comment
X-ray structures of catalyst intermediates and DFT calculations support the shown mechanism. While the conversion of aromatic alkyl halides proceeded smoothly, purely aliphatic halides showed no reaction or gave only traces of product.
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Publikationsverlauf
Artikel online veröffentlicht:
16. August 2024
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