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Drug Res (Stuttg) 2018; 68(05): 280-285
DOI: 10.1055/s-0043-120197
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Facile Synthesis and Characterization of L-Aspartic Acid Coated Iron Oxide Magnetic Nanoparticles (IONPs) For Biomedical Applications

Marziyeh Salehiabar
1   Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
,
Hamed Nosrati
2   Department of pharmaceutical biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
,
Soodabeh Davaran
3   Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
,
Hossein Danafar
1   Zanjan Pharmaceutical Nanotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
,
Hamidreza Kheiri Manjili
4   Zanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
› Author Affiliations
Further Information

Publication History

received 08 July 2017

accepted 20 September 2017

Publication Date:
16 October 2017 (online)

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Abstract

Natural L-aspartic acid coated iron oxide magnetic nanoparticles (Asp@IONPs) were prepared by a one pot, in-situ and green co–precipitation method in an aqueous medium. Functionalized iron oxide magnetic nanoparticles (IONPs) were characterized by Vibrating Sample Magnetometer (VSM), X-ray diffraction (XRD), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), Scanning electron microscopy (SEM) and Transmission electron microscopy (TEM) techniques. Cellular toxicity of IONPs was also investigated on HEK-293 cell lines. The results showed that the zeta potential of Asp@IONPs was about −21.1 mV and the average size was 17.80±3.09 nm. Cell toxicity results show that as prepared IONPs are biocompatible. Asp@IONPs show the possibility of using these nanoparticles in the development of in vitro and in vivo biomedical fields due to do not possess a toxic effect, good ζ-potential and related small and narrow size distribution.

Key words

Iron oxide magnetic nanoparticles - Amino acid - Functionalization - L-Aspartic acid - Cell toxicity
 

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