Exp Clin Endocrinol Diabetes 2018; 126(05): 316-320
DOI: 10.1055/s-0043-120110
Article
© Georg Thieme Verlag KG Stuttgart · New York

Evaluation of the Relation Between Omentin-1 and Vitamin D in Postmenopausal Women With or Without Osteoporosis

Authors

  • Okan Dikker

    1   Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
    3   Department of Medical Biochemistry, Okmeydani Training and Research Hospital, Okmeydani, Istanbul, Turkey
  • Seldag Bekpinar

    1   Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
  • Gul Ozdemirler

    2   Department of Medical Biochemistry,Faculty of Medicine, Halic University, Sutluce Istanbul, Turkey
  • Mujdat Uysal

    1   Department of Medical Biochemistry, Istanbul Faculty of Medicine, Istanbul University, Capa, Istanbul, Turkey
  • Muberra Vardar

    3   Department of Medical Biochemistry, Okmeydani Training and Research Hospital, Okmeydani, Istanbul, Turkey
  • Sevgi Atar

    4   Department of Physical Therapy and Rehabilitation, Okmeydani Training and Research Hospital, Okmeydani, Istanbul, Turkey
  • Murat Usta

    5   Department of Medical Biochemistry, Giresun University, Faculty of Medicine, Nizamiye Giresun, Turkey
  • Berrin Huner

    4   Department of Physical Therapy and Rehabilitation, Okmeydani Training and Research Hospital, Okmeydani, Istanbul, Turkey
Further Information

Publication History

received 01 June 2017
first decision 14 September 2017

accepted 21 September 2017

Publication Date:
08 November 2017 (online)

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Abstract

Introduction Crosstalk between bone and adipose tissues is implicated in several pathologic conditions related to bone metabolism. Omentin-1, a 34-kD protein, is released from omental adipose tissue. A few studies indicated the effect of omentin-1 on bone health and bone mineral density (BMD) and the interaction of omentin-1 with vitamin D. Therefore, this study aimed to investigate the relationship between omentin-1, vitamin D, and BMD in postmenopausal women with osteoporosis compared with non-osteoporotic counterparts.

Materials and methods Forty postmenopausal women with osteoporosis (OP), 40 counterparts without OP, and 30 premenopausal women were enrolled. Dual-energy X-ray Absorptiometry results, body mass index, and some demographic and biochemical data were recorded. Vitamin D (25-hydroxyvitamin D3) levels were measured using liquid chromatography-tandem mass spectrometry. Serum omentin-1 was determined using an enzyme-linked immunosorbent assay.

Results Omentin-1 levels tended to increase in both postmenopausal women groups compared with the control group, but this increase was significant only in women with osteoporosis. Vitamin D levels were not different between the groups. When women were categorized according to vitamin D levels, women with normal vitamin D levels had significantly higher omentin-1 levels. A positive correlation was found between omentin-1 and vitamin D levels in all groups (r=0.197, p=0.041, n=110).

Conclusion The tendency to an increase in omentin-1 levels in postmenopausal women with osteoporosis may be due to a physiologic compensation against bone loss after menopause. The linear relationship between omentin-1 and vitamin D suggests that adipose tissue is one of the target tissues for the vitamin D effect.