Abstract
The frequency of Bacillus subtilis infection such as pneumonia pan-opthalmitis, visceral
abscess or musculoskeletal infection etc. complications following bacteremia, meningitis
in children & the infection associated with majority of motor vehicle accidents associated
with trauma & gun shoot injury. Antibiotics which appear especially useful in the
treatment of Bacillus. infection are clindamycin and vancomycin to which vast majority
of strains are susceptible in vitro. Our objective is to test the synthesized peptidomimetics
with the efforts mainly directed towards the identification of antibacterial compounds
against recurrent septicemia infection. Six peptidomimetics namely G-A-L-D (C60-soot Glu-ala-leu-Asp), D-P-F (C60-soot Asp-pro-Phe), I-R (C60-soot Ile-Arg), L-R (C60-soot leu-Arg), E-R (C60-soot Glu-Arg), D-E (C60-soot Asp-Glu), the column eluted compounds were tested for disc diffusion using gram
positive Bacillus Subtilis strains at different concentrations predicted by pH and
inhibitory concentrations. I-R (C60-soot Ile-Arg), & D-E (C60-soot Asp-Glu) was found to be very effective along with 5 compounds against Bacillus
Subtilis strain tested. Maximum activity 100 µg/ml for synthesized peptidomimetics
with the corresponding zonal inhibition diameter (11 mm; 11 mm; 14 mm; 11 mm; 11 mm;
14 mm) against Bacillus subtilis strain. This is the first evidence based report that
proves I-R (C60-soot Ile-Arg) & D-E (C60-soot Asp-Glu) has shown antibacterial action against gram positive strains of Bacillus
Subtilis against recurrent septicemia infection
Key words
bacillus subtilis - antibacterial drug - drug research & Infectious disease
