Netzhautablösung im Kindesalter

Petra Meier

doi:10.1055/s-0043-106301

Klinische Monatsblätter für Augenheilkunde, Table of Contents

Klin Monbl Augenheilkd 2019; 236(01): 74-87
DOI: 10.1055/s-0043-106301

Übersicht

Georg Thieme Verlag KG Stuttgart · New York

Netzhautablösung im Kindesalter

Pediatric Retinal Detachment

Authors

Petra Meier

Klinik und Poliklinik für Augenheilkunde, Universität Leipzig

Abstract

Zusammenfassung

Eine Ablatio retinae tritt im Kindesalter im Vergleich zum Erwachsenenalter relativ selten auf, nur 3 bis 7% aller Netzhautablösungen werden bei Kindern und Jugendlichen im Alter bis zu 18 Jahren diagnostiziert. Risikofaktoren für das Auftreten einer Ablatio retinae im Kindesalter sind ein Trauma, eine Myopie, hereditäre Vitreoretinopathien, Malformationen und Morbus Coats. Am häufigsten treten in dieser Altersgruppe traumaassoziierte Netzhautablösungen auf, Vitreoretinopathien sind die häufigste Ursache für eine erblich bedingte kindliche Ablatio. Es werden die krankheitsspezifischen chirurgischen Behandlungskonzepte diskutiert. Bei klarer Linse sollte immer geprüft werden, inwieweit eine episklerale Buckelchirurgie durchgeführt werden kann, insbesondere bei einer Oradialyse und bei genau definierter Lochsituation in der Netzhautperipherie. Eine primäre Vitrektomie ist vorrangig bei Vitreoretinopathien erforderlich. Der Einsatz von Anti-VEGF-Inhibitoren ist zur Behandlung vasoproliferativer Erkrankungen geeignet, allerdings benötigen wir noch weitere Informationen über mögliche Nebenwirkungen bei Kindern. Insgesamt sind die funktionellen und anatomischen Behandlungsergebnisse bei Kindern oftmals schlechter als vergleichbare Resultate bei Erwachsenen. Weitere chirurgische Innovationen und ätiologiespezifische Therapiekonzepte sind erforderlich, um die Ergebnisse in dieser Patientengruppe zu verbessern.

Abstract

The number of retinal detachments in children is rarely compared to the number of retinal detachments in adults; only 3 – 7% occur in children. The main predisposing factors are trauma, myopia, hereditary vitreoretinopathies, retinopathy of prematurity, malformations and Coatsʼ disease. The most frequent paediatric retinal detachments are trauma-associated and vitreoretinopathies are the most common cause of inherited retinal detachment. Disease-specific surgical treatments are discussed. Episcleral buckling surgery should be the preferred method in any case of clear lens, especially for treatment of oradialysis and well-defined localization of peripherally retinal tears. In those suffering from vitreoretinopathy, primary vitrectomy is necessary. The intravitreal use of VEGF-inhibitors to treat vasoproliferative retinopathy in children is a new and effective tool, but we need further results about safety and side-effects in young patients. The functional and anatomical outcomes of retinal detachment in children are less successful than in adults. Further surgical innovations and etiology-specific treatment strategies are required to improve the outcome in this group.

Schlüsselwörter

Kinderophthalmologie - vitreoretinale Chirurgie - kindliche Netzhautablösung

Key words

paediatric retinal detachment - vitreoretinal surgery - paediatric ophthalmology

Full Text

References

Literatur
1 Meier P, Wiedemann P. Surgery for pediatric vitreoretinal Disorders. In: Ryan SJ, Wilkinson CP, Wiedemann P. eds. Retina. 5th ed. London, New York, Oxford, St Louis, Sydney, Toronto: Elsevier; 2013: 1933-1953
2 Sarrazin L, Averbukh E, Halper M. et al. Traumatic pediatric retinal detachment: a comparison between open and closed globe injuries. Am J Ophthalmol 2004; 137: 1042-1049
3 Wang NK, Chen YP, Yeung L. et al. Traumatic pediatric retinal detachment following open globe injury. Ophthalmologica 2007; 221: 255-263
4 Haring G, Wiechens B. Long-term results after scleral buckling surgery in uncomplicated juvenile retinal detachment without proliferative vitreoretinopathy. Retina 1998; 18: 501-505
5 Errera MH, Liyanage SE, Moya R. Primary scleral buckling for pediatric rhegmatogenous retinal detachment. Retina 2015; 35: 1441-1449
6 Boiko E, Shishkin M, Dolgih V. Indications for the encircling buckle (EB) procedure in severe open-globe eye injury (OGI). Meeting abstract; 2008. Im Internet: http://www.egms.de/static/de/meetings/rg2008/08rg024.shtml Stand: 18.06.2008
7 Sheard RM, Mireskandari K, Ezra E. et al. Vitreoretinal surgery after childhood ocular trauma. Eye (Lond) 2007; 21: 793-798
8 Kuhn F. ed. Ocular Trauma in Children and elderly Patients. Berlin, Heidelberg, New York: Springer; 2008: 417-435
9 Fivgas GD, Capone jr. A. Pediatric rhegmatogenous retinal detachment. Retina 2001; 21: 101-106
10 Wang NK, Tsai CH, Chen YP. et al. Pediatric rhegmatogenous retinal detachment in East Asians. Ophthalmology 2005; 112: 1890-1895
11 Lee RW, Mayer EJ, Markham RH. The aetiology of paediatric rhegmatogenous retinal detachment: 15 years experience. Eye (Lond) 2008; 22: 636-640
12 Ono Y, Uehara K, Haruta M. et al. Characteristics and surgical outcomes of pediatric rhegmatogenous retinal detachment. Clin Ophthalmol 2012; 6: 939-943
13 Feltgen N, Weiss C, Wolf S. et al. Scleral buckling versus primary vitrectomy in rhegmatogenous retinal detachment study (SPR Study): recruitment list evaluation. Study report no 2. Graefes Arch Clin Exp Ophthalmol 2007; 245: 803-809
14 Bansal AS, Hubbard 3rd GB. Peripheral retinal findings in highly myopic children < or = 10 years of age. Retina 2010; 30 (Suppl. 04) S15-S19
15 Meier P. Hereditäre Vitreoretinopathien und Netzhautablösung im Kindesalter. Klin Monatsbl Augenheilkd 2013; 230: 914-919
16 Stickler GB, Belau PG, Farrell FJ. et al. Hereditary progressive arthro-ophthalmopathy. Mayo Clin Proc 1965; 40: 433-455
17 Carroll C, Papaioannou D, Rees A. et al. The clinical effectiveness and safety of prophylactic retinal interventions to reduce the risk of retinal detachment and subsequent vision loss in adults and children with Stickler syndrome: a systematic review. Health Technol Assess 2011; 15: iii-xiv 1–62
18 Snead MP, Yates JR. Clinical and molecular genetics of Stickler syndrome. J Med Genet 1999; 36: 353-359
19 Snead MP, McNinch AM, Poulson AV. et al. Stickler syndrome, ocular-only variants and a key diagnostic role for the ophthalmologist. Eye (Lond) 2011; 25: 1389-1400
20 Ang A, Poulson AV, Goodburn SF. et al. Retinal detachment and prophylaxis in type 1 Stickler syndrome. Ophthalmology 2008; 115: 164-168
21 Stickler GB, Hughes W, Houchin P. Clinical features of hereditary progressive arthro-ophthalmopathy (Stickler syndrome): a survey. Genet Med 2001; 3: 192-196
22 Reddy DN, Yonekawa Y, Thomas BJ. et al. Long-term outcomes of retinal detachment in patients with Stickler syndrome. Clin Ophthalmol 2016; 16: 1531-1534
23 Abeysiri P, Bunce C, da Cruz L. Outcomes of surgery for retinal detachment in patients with Stickler syndrome: a comparison of two sequential 20-year cohorts. Graefes Arch Clin Exp Ophthalmol 2007; 245: 1633-1638
24 Fincham GS, Pasea L, Carroll C. et al. Prevention of retinal detachment in Stickler syndrome: the Cambridge prophylactic cryotherapy protocol. Ophthalmology 2014; 121: 1588-1597
25 Leiba H, Oliver M, Pollack A. Prophylactic laser photocoagulation in Stickler syndrome. Eye (Lond) 1996; 10: 701-708
26 Arslan-Kirchner M, von Kodolitsch Y, Schmidtke J. The importance of genetic testing in the clinical management of patients with Marfan syndrome and related disorders. Dtsch Arztebl Int 2008; 105: 483-491
27 Dotrelova D, Karel I, Clupkova E. Retinal detachment in Marfanʼs syndrome. Retina 1997; 17: 390-396
28 Nement AY, Assia EL, Apple DJ. et al. Current concepts of ocular manifestations in Marfan syndrome. Surv Ophthalmol 2006; 51: 561-575
29 Rahmani S, Lyon AT, Fawzi AA. et al. Retinal disease in Marfan syndrome: from the Marfan Eye Consortium of Chicago. Ophthalmic Surg Lasers Imaging Retina 2015; 46: 936-941
30 Loewenstein A, Barequet I, de Juan E. et al. Retinal detachment in Marfan syndrome. Retina 2000; 20: 358-363
31 Sharma T, Gopal L, Shanmugam MP. et al. Retinal detachment in Marfan syndrome. Retina 2002; 22: 423-428
32 Lee SY, Ang CL. Results of retinal detachment surgery in Marfan syndrome in Asians. Retina 2003; 23: 24-29
33 Abboud EB. Retinal detachment surgery in Marfanʼs syndrome. Retina 1998; 18: 405-409
34 George ND, Yates JR, Bradshaw K. et al. Infantile presentation of X linked retinoschisis. Br J Ophthalmol 1995; 79: 653-657
35 Sauer CG, Gehrig A, Warneke-Wittstock R. et al. Positional cloning of the gene associated with X-linked juvenile retinoschisis. Nat Genet 1997; 17: 164-170
36 Gregori NZ, Lam BL, Gregori G. et al. Wide-field spectral-domain optical coherence tomography in patients and carriers of X-linked retinoschisis. Ophthalmology 2013; 120: 169-174
37 Gregori NZ, Berrocal AM, Gregori G. et al. Macular spectral-domain optical coherence tomography in patients with X-linked retinoschisis. Br J Ophthalmol 2009; 93: 373-378
38 Prenner JL, Capone jr. A, Ciaccia S. et al. Congenital X-linked retinoschisis classification system. Retina 2006; 26: 61-64
39 George ND, Payne SJ, Bill RM. Improved genetic mapping of X linked retinoschisis. J Med Genet 1996; 33: 919-922
40 Tantri A, Vrabec TR, Cu-Unjieng A. et al. X-linked retinoschisis: a clinical and molecular genetic review. Surv Ophthalmol 2004; 49: 214-230
41 Wu WC, Drenser KA, Capone A. et al. Plasmin enzyme-assisted vitreoretinal surgery in congenital X-linked retinoschisis: surgical techniques based on a new classification system. Retina 2007; 27: 1079-1085
42 Garcia-Arumi J, Corcostegui IA, Navarro R. et al. Vitreoretinal surgery without schisis cavity excision for the management of juvenile X linked retinoschisis. Br J Ophthalmol 2008; 92: 1558-1560
43 Ikeda F, Iida T, Kishi S. Resolution of retinoschisis after vitreous surgery in X-linked retinoschisis. Ophthalmology 2008; 115: 718-722
44 Lee JJ, Kim JH, Kim SY. Infantile vitreous hemorrhage as the initial presentation of X-linked juvenile retinoschisis. Korean J Ophthalmol 2009; 23: 118-120
45 Yu H, Li T, Luo Y. et al. Long-term outcomes of vitrectomy for progressive X-linked retinoschisis. Am J Ophthalmol 2012; 154: 394-402
46 Gupta MP, Parlitsis G, Tsang S. et al. Resolution of foveal schisis in X-linked retinoschisis in the setting of retinal detachment. J AAPOS 2015; 19: 172-174
47 Ferrone PJ, Trese MT, Lewis H. Vitreoretinal surgery for complications of congenital retinoschisis. Am J Ophthalmol 1997; 123: 742-747
48 Trese MT. Enzymatic-assisted vitrectomy. Eye (Lond) 2002; 16: 365-368
49 Criswick VG, Schepens CL. Familial exudative vitreoretinopathy: a report of two cases. Am J Ophthalmology 1969; 68: 578-594
50 Gilmour DF. Familial exudative vitreoretinopathy and related retinopathies. Eye (Lond) 2015; 29: 1-14
51 Pendergast SD, Trese M. Familial exudative vitreoretinopathy. Results of surgical management. Ophthalmology 1998; 105: 1015-1023
52 Kashani AH, Brown KT, Chang E. Diversity of retinal vascular anomalies in patients with familial exudative vitreoretinopathy. Ophthalmology 2014; 121: 2220-2227
53 Henry CR, Sisk RA, Tzu JH. et al. Long-term follow-up of intravitreal bevacizumab for the treatment of pediatric retinal and choroidal diseases. J AAPOS 2015; 19: 541-548
54 Quiram PA, Drenser KA, Lai MM. et al. Treatment of vascularly active familial exudative vitreoretinopathy with pegaptanib sodium (Macugen). Retina 2008; 28: 8-12
55 Tagami M, Kusuhara S, Honda S. et al. Rapid regression of retinal hemorrhage and neovascularization in a case of familial exudative vitreoretinopathy treated with intravitreal bevacizumab. Graefes Arch Clin Exp Ophthalmol 2008; 246: 1787-1789
56 Yamane T, Yokoi T, Nakayama Y. Surgical outcomes of progressive tractional retinal detachment associated with familial exudative vitreoretinopathy. Am J Ophthalmol 2014; 158: 1049-1055
57 Hocaoglu M, Karacorlu M, Sayman Muslubas I. Anatomical and functional outcomes following vitrectomy for advanced familial exudative vitreoretinopathy: a single surgeonʼs experience. Br J Ophthalmol 2016;
58 Glazer LC, Maguire A, Blumenkranz MS. et al. Improved surgical treatment of familial exudative vitreoretinopathy in children. Am J Ophthalmol 1995; 120: 471-479
59 Ranchod TM, Ho LY, Drenser KA. et al. Clinical presentation of familial exudative vitreoretinopathy. Ophthalmology 2011; 118: 2070-2075
60 Lyu J, Zhang Q, Wang SY. et al. Ultra-wide-field scanning laser ophthalmoscopy assists in the clinical detection and evaluation of a symptomatic early-stage familial exudative vitreoretinopathy. Graefes Arch Clin Exp Ophthalmol 2017; 255: 39-47
61 Shields JA, Shields CL, Honavar SG. et al. Classification and management of Coats disease: the 2000 proctor lecture. Am J Ophthalmol 2001; 131: 572-583
62 Sigler EJ, Randolph JC, Calzada JI. et al. Current management of Coats disease. Surv Ophthalmol 2014; 59: 30-46
63 Obana A, Miki T, Matsumoto M. et al. [An experimental and clinical study of chorioretinal photocoagulation using a frequency-doubled Nd : YAG laser]. Nippon Ganka Gakkai Zasshi 1993; 97: 1040-1046
64 Blair MP, Ulrich JN, Elizabeth Hartnett M. et al. Peripheral retinal nonperfusion in fellow eyes in Coats disease. Retina 2013; 33: 1694-1699
65 Haik BG. Advanced Coatsʼ disease. Trans Am Ophthalmol Soc 1991; 89: 371-476
66 Zheng XX, Jiang YR. The effect of intravitreal bevacizumab injection as the initial treatment for Coatsʼ disease. Graefes Arch Clin Exp Ophthalmol 2014; 252: 35-42
67 Lin CJ, Hwang JF, Chen YT. et al. The effect of intravitreal bevacizumab in the treatment of Coats disease in children. Retina 2010; 30: 617-622
68 Mrejen S, Metge F, Denion E. et al. Management of retinal detachment in Coats disease. Study of 15 cases. Retina 2008; 28: 26-32
69 Gaillard MC, Mataftsi A, Balmer A. et al. Ranibizumab in the management of advanced Coats disease stages 3B and 4: long-term outcomes. Retina 2014; 34: 2275-2281
70 Cai X, Zhao P, Zhang Q. et al. Treatment of stage 3 Coatsʼ disease by endolaser photocoagulation via a two-port pars plana nonvitrectomy approach. Graefes Arch Clin Exp Ophthalmol 2015; 253: 999-1004
71 Stanga PE, Jaberansari H, Bindra MS. et al. Transscleral drainage of subretinal fluid, anti-vascular endothelial growth factor, and wide-field imaging-guides laser in Coats exudative retinal detachment. Retina 2016; 36: 156-162
72 Shen T, Liu R, Lin J. et al. Pars plana vitrectomy and evisceration resulting in death due to misdiagnosis of retinoblastoma in children: A review of 3 cases. Medicine (Baltimore) 2015; 94: e1338
73 Jumper JM, Pomerleau D, McDonald HR. et al. Macular fibrosis in Coats disease. Retina 2010; 30: 9-14
74 Sigler EJ, Calzada JI. Retinal angiomatous proliferation with chorioretinal anastomosis in childhood Coats disease: a reappraisal of macular fibrosis using multimodal imaging. Retina 2015; 35: 537-546
75 Müller B, Joussen AM. [Childhood retinal detachment: ROP and myopia]. Klin Monatsbl Augenheilkd 2013; 230: 894-901
76 [Anonymous] An international classification of retinopathy of prematurity. II. The classification of retinal detachment. The International Committee for the Classification of the Late Stages of Retinopathy of Prematurity. Arch Ophthalmol 1987; 105: 906-912
77 Kaiser RS, Trese M, Williams GA. et al. Adult retinopathy of prematurity: outcome of rhegmatogenous retinal detachment and retinal tears. Ophthalmology 2001; 108: 1647-1653
78 Park KH, Hwang JM, Choi MY. et al. Retinal detachment of regressed retinopathy of prematurity in children aged 2 to 15 years. Retina 2004; 24: 368-375
79 Tasman W, Patz A, McNamara JA. et al. Retinopathy of prematurity: the life of a lifetime disease. Am J Ophthalmol 2006; 141: 167-174
80 Machemer R. Late traction detachment in retinopathy of prematurity or ROP-like cases. Graefes Arch Clin Exp Ophthalmol 1993; 23: 389-394
81 Jandeck C, Kellner U, Foerster MH. [Late retinal complications in former preterm infants with regressed ROP]. Klin Monatsbl Augenheilkd 2004; 221: 96-100
82 Tufail A, Singh AJ, Haynes RJ. Late onset vitreoretinal complications of regressed retinopathy of prematurity. Br J Ophthalmol 2004; 88: 243-246
83 Geloneck MM, Chuang AZ, Clark WL. et al. Refractive outcomes following bevacizumab monotherapy compared with conventional laser treatment: a randomized clinical trial. JAMA Ophthalmol 2014; 132: 1327-1333
84 Haik BG, Greenstein SH, Smith ME. et al. Retinal detachment in the morning glory anomaly. Ophthalmology 1984; 97: 1638-1647
85 Georgalas I, Ladas I, Georgopoulos G. et al. Optic disc pit: a review. Graefes Arch Clin Exp Ophthalmol 2011; 249: 1113-1122
86 Ho CL, Wei LC. Rhegmatogenous retinal detachment in morning glory syndrome pathogenesis and treatment. Int Ophthalmol 2001; 24: 21-24
87 Coll GE, Chang S, Flynn TE. et al. Communication between the subretinal space and the vitreous cavity in the morning glory syndrome. Graefes Arch Clin Exp Ophthalmol 1995; 233: 441-443
88 Jo YJ, Iwase T, Oveson BC. et al. Retinal detachment in morning glory syndrome with large hole in the excavated disc. Eur J Ophthalmol 2011; 21: 841-844
89 Chang S, Gregory-Roberts E, Chen R. Retinal detachment associated with optic disc colobomas and morning glory syndrome. Eye (Lond) 2012; 26: 494-500
90 Postel EA, Pulido JS, McNamara JA. et al. The etiology and treatment of macular detachment associated with optic nerve pits and related anomalies. Trans Am Ophthalmol Soc 1998; 96: 73-93
91 Jain N, Johnson MW. Pathogenesis and treatment of maculopathy associated with cavitary optic disc anomalies. Am J Ophthalmol 2014; 158: 423-435
92 Teke MY, Citirik M. 23 gauge vitrectomy, endolaser, and gas tamponade versus vitrectomy alone for serous macular detachment associated with optic disc pit. Am J Ophthalmol 2015; 160: 779-785
93 Abouammoh MA, Alsulaiman SM, Gupta VS. et al. Pars plana vitrectomy with juxtapapillary laser photocoagulation versus vitrectomy without juxtapapillary laser photocoagulation for the treatment of optic disc pit maculopathy: the results of the KKESH International Collaborative Retina Study Group. Br J Ophthalmol 2016; 100: 478-483
94 Rayat JS, Rudnisky CJ, Waite C. et al. Long-term outcomes for optic disk pit maculopathy after vitrectomy. Retina 2015; 35: 2011-2017
95 Georgalas I, Ladas I, Georgopoulos G. et al. Optic disc pit: a review. Graefes Arch Clin Exp Ophthalmol 2011; 249: 1113-1122
96 Gopal L, Badrinath SS, Sharma T. et al. Surgical management of retinal detachments related to coloboma of the choroid. Ophthalmology 1998; 105: 804-809
97 Arevalo JF, Lasave AF, Arevalo FA. et al. Rhegmatogenous retinal detachment and bilateral optic disc coloboma in organoid nevus syndrome. JAMA Ophthalmol 2013; 131: 111-113
98 Tansu E, Serhad N. Optical coherence tomography after pars plana vitrectomy for retinal detachment related to choroidal coloboma. Retina 2010; 30: 1078-1083
99 Ferrone PJ. Treatment of retinal detachment associated with optic nerve head coloboma. J AAPOS 2012; 16: 5
100 Shami M, McCartney D, Benedict W. et al. Spontaneous retinal reattachment in a patient with persistent hyperplastic primary vitreous and an optic nerve coloboma. Am J Ophthalmol 1992; 114: 769-771
101 Dureau P, Attie-Bitach T, Salomon R. et al. Renal coloboma syndrome. Ophthalmology 2001; 108: 1912-1916
102 Uhumwangho OM, Jalali S. Chorioretinal coloboma in a paediatric population. Eye (Lond) 2014; 28: 728-733
103 Sanghvi DA, Sanghvi CA, Purandare NC. Bilateral persistent hyperplastic primary vitreous. Australas Radiol 2005; 49: 72-74
104 Shastry BS. Persistent hyperplastic primary vitreous: congenital malformation of the eye. Clin Experiment Ophthalmol 2009; 37: 884-890
105 Kirchhoff B, Völcker HE, Naumann GOH. Glaskörper. In: Apple DJ. Hrsg. Pathologie des Auges. 2. Aufl.. Berlin, Heidelberg, New York: Springer; 1997: 955-994
106 Walsh MK, Drenser KA, Capone jr. A. et al. Early vitrectomy effective for bilateral combined anterior and posterior persistent fetal vasculature syndrome. Retina 2010; 30: 2-8
107 Dass AB, Trese MT. Surgical results of persistent hyperplastic primary vitreous. Ophthalmology 1999; 106: 280-284