Planta Med 2022; 88(15): 1434
DOI: 10.1055/s-0042-1758993
Poster Session I

Validation of the traditional use of Achillea moschata Wulfen at gastric level: an ethnopharmacological approach

G Martinelli∗
1   University of Milan – Department of Pharmacological and Biomolecular Sciences (DiSFeB) Via Balzaretti 9, 20133 Milan, Italy
,
N Maranta
1   University of Milan – Department of Pharmacological and Biomolecular Sciences (DiSFeB) Via Balzaretti 9, 20133 Milan, Italy
,
M Bottoni
2   University of Milan – Department of Pharmaceutical Sciences (DISFARM), Via Luigi Mangiagalli 25, 20133 Milan, Italy
3   Ghirardi Botanic Garden – Department of Pharmaceutical Sciences (DISFARM), Via Religione 25, 25088 Toscolano Maderno, Brescia, Italy
,
S Piazza
1   University of Milan – Department of Pharmacological and Biomolecular Sciences (DiSFeB) Via Balzaretti 9, 20133 Milan, Italy
,
A Magnavacca
1   University of Milan – Department of Pharmacological and Biomolecular Sciences (DiSFeB) Via Balzaretti 9, 20133 Milan, Italy
,
M Fumagalli
1   University of Milan – Department of Pharmacological and Biomolecular Sciences (DiSFeB) Via Balzaretti 9, 20133 Milan, Italy
,
C Pozzoli
1   University of Milan – Department of Pharmacological and Biomolecular Sciences (DiSFeB) Via Balzaretti 9, 20133 Milan, Italy
,
E Sangiovanni
1   University of Milan – Department of Pharmacological and Biomolecular Sciences (DiSFeB) Via Balzaretti 9, 20133 Milan, Italy
,
C Giuliani
2   University of Milan – Department of Pharmaceutical Sciences (DISFARM), Via Luigi Mangiagalli 25, 20133 Milan, Italy
3   Ghirardi Botanic Garden – Department of Pharmaceutical Sciences (DISFARM), Via Religione 25, 25088 Toscolano Maderno, Brescia, Italy
,
F Milani
2   University of Milan – Department of Pharmaceutical Sciences (DISFARM), Via Luigi Mangiagalli 25, 20133 Milan, Italy
3   Ghirardi Botanic Garden – Department of Pharmaceutical Sciences (DISFARM), Via Religione 25, 25088 Toscolano Maderno, Brescia, Italy
,
L Colombo
2   University of Milan – Department of Pharmaceutical Sciences (DISFARM), Via Luigi Mangiagalli 25, 20133 Milan, Italy
3   Ghirardi Botanic Garden – Department of Pharmaceutical Sciences (DISFARM), Via Religione 25, 25088 Toscolano Maderno, Brescia, Italy
,
P Sira Colombo
2   University of Milan – Department of Pharmaceutical Sciences (DISFARM), Via Luigi Mangiagalli 25, 20133 Milan, Italy
3   Ghirardi Botanic Garden – Department of Pharmaceutical Sciences (DISFARM), Via Religione 25, 25088 Toscolano Maderno, Brescia, Italy
,
P Bruschi
4   University of Florence – Department of Agricultural, Environmental, Food and Forestry Science and Technology (DAGRI), Piazzale delle Cascine 18, 50144 Florence, Italy
,
G Fico
2   University of Milan – Department of Pharmaceutical Sciences (DISFARM), Via Luigi Mangiagalli 25, 20133 Milan, Italy
3   Ghirardi Botanic Garden – Department of Pharmaceutical Sciences (DISFARM), Via Religione 25, 25088 Toscolano Maderno, Brescia, Italy
,
M DellʼAgli
1   University of Milan – Department of Pharmacological and Biomolecular Sciences (DiSFeB) Via Balzaretti 9, 20133 Milan, Italy
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Traditional plant knowledge in mountain areas has become an essential source of ethnomedicinal findings, basis for the selection of plants as potential source of new bioactive compounds [1]. In this context, an ethnobotanical survey, part of the European Interreg Italy-Switzerland B-ICE project, investigated the traditional uses of the autochthonous plant species in Valmalenco (Sondrio, Italy). From 2019 to 2022, a total of 401 informants were interviewed. The inflorescences of Achillea moschata Wulfen were 40%-mentioned for the use in digestive tract disorders, such as gastritis, an inflammatory-based disease often associated with Helicobacter pylori.

The present research aims at verifying the potential traditional properties of Achillea moschata Wulfen inflorescence extract at this level.

Infusion, decoction, and ethanol : water (50 : 50) extracts were prepared, in order to compare traditional preparations and different extraction solvents. The phytochemical profile of the extracts showed similar quali- and quantitative content of polyphenols, correlating with the activity at biological level. The extracts had similar anti-inflammatory activity when studied in an in vitro model of non-tumoral gastric epithelial cells (GES-1) stimulated with TNF-α or H. pylori-infection. The preparations inhibited the NF-κB driven transcription, IL-8, and IL-6 release, with IC50s ranging from 30 to 100 µg/mL. The anti-bacterial effect was assessed on H. pylori by evaluating the minimum inhibitory concentration (MIC): the extracts showed activity starting from 100 µg/mL.

This is the first study demonstrating the anti-inflammatory and anti-bacterial properties of traditional preparations of Achillea moschata Wulfen inflorescences against H. pylori-related gastritis.

The authors have no conflict of interest to declare.



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Artikel online veröffentlicht:
12. Dezember 2022

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  • Reference

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