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Synfacts 2023; 19(03): 0311
DOI: 10.1055/s-0042-1753295
DOI: 10.1055/s-0042-1753295
Peptide Chemistry
Cu-Catalyzed Introduction of Oxime Ethers into Peptides
Authors
Liu Y,
He Z,
Ma W,
Bao G,
Li Y,
Yu C,
Li J,
R. E
Xu Z,
*,
Wang R,
*,
Sun W.
*
Lanzhou University, P. R. of China
Copper(I)-Catalyzed Late-Stage Introduction of Oxime Ethers into Peptides at the Carboxylic Acid Site.
Org. Lett. 2022;
24: 9284-9253
DOI: 10.1021/acs.orglett.2c03813
Copper(I)-Catalyzed Late-Stage Introduction of Oxime Ethers into Peptides at the Carboxylic Acid Site.
Org. Lett. 2022;
24: 9284-9253
DOI: 10.1021/acs.orglett.2c03813
Significance
For a long time, the development of late-stage modifications to peptides has been an important endeavor to organic chemists. In this study the authors have successfully demonstrated a copper-catalyzed introduction of oxime ethers to peptides.
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Comment
This copper catalysis is a promising method for the introduction of biological fragments into peptides. This method was successfully performed with various peptides in excellent yields.
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Publication History
Article published online:
13 February 2023
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