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Synfacts 2023; 19(08): 0826
DOI: 10.1055/s-0042-1752722
Innovative Drug Discovery and Development

Discovery of ACT-774312: A Potent and Selective CRTH2 Receptor Antagonist

Authors

    Contributor(s):

  • Antonia F. Stepan (Roche)

  • Thomas Puleo (Pfizer)

  • Danica A. Rankic (Pfizer)

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Key words

ACT-774312 - plasma shift - CRTH2 receptor - allergic diseases - Fischer indole synthesis - isosteres - scaffold hop


Publication History

Article published online:
14 July 2023

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