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Synfacts 2023; 19(04): 0415
DOI: 10.1055/s-0042-1752649
Innovative Drug Discovery and Development

Macrocyclization and Scaffold Hopping Improves Selectivity and ADME Properties of HPK1 Inhibitors

Authors

    Contributor(s):

  • Antonia F. Stepan (Roche)

  • Ferdinand H. Lutter (Janssen Pharmaceutica)

  • Ulrich Lücking (FoRx Therapeutics)

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Key words

macrocycles - kinase inhibition - selectivity - ADME - scaffold hopping


Publication History

Article published online:
17 March 2023

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