PDF icon Download PDF
Synfacts 2023; 19(04): 0424
DOI: 10.1055/s-0042-1752640
Peptide Chemistry

Synthesis of N-Formyl Amino Acid Esters

Contributor(s):
Hisashi Yamamoto
,
Isai Ramakrishna
Giard T, *, Bénard D, Plaquevent J.-C. Laboratoire des Fonctions Azotées et Oxygénées Complexes de l'IRCOF, Mont Saint Aignan, France
A Mild Method for Formylating Amino Esters Without Using any Formylating Agent.

Synthesis 1998; 297-300
DOI: 10.1055/s-1998-2025
Thieme ConnectSearch in Google Scholar
› Further Information
 
 PDF Download Permissions and Reprints

Key words

formylation - amino acid esters - oxaziridines

Significance

N-Formyl amino acids and peptides play a crucial role in peptide drug discovery. Thus, synthetic chemists are in search of mild and simple methods for the synthesis of N-formyl amino acids. In 1998, Giard and co-workers developed a simple method for the synthesis of N-formyl amino acid esters without using formylating agents.


 

Comment

A series of N-formyl amino acid esters were synthesized in three steps with excellent yields without using any formylating agent. This protocol is practically simple, mild, and proceeds without racemization.


 

 

Publication History

Article published online:
17 March 2023

© 2023. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany


  Permissions and Reprints