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Synfacts 2023; 19(05): 0521
DOI: 10.1055/s-0042-1752485
DOI: 10.1055/s-0042-1752485
Peptide Chemistry
Ir-Catalyzed Enantio- and Diastereoselective Synthesis of 3-Substituted Proline Derivatives
Che C,
Lu Y.-N,
Wang C.-J.
*
Wuhan University and Nankai University, Tianjin, P. R. of China
Enantio- and Diastereoselective De Novo Synthesis of 3-Substituted Proline Derivatives via Cooperative Photoredox/Brønsted Acid Catalysis and Epimerization.
J. Am. Chem. Soc. 2023;
145: 2779-2786
DOI: 10.1021/jacs.2c12995.
Enantio- and Diastereoselective De Novo Synthesis of 3-Substituted Proline Derivatives via Cooperative Photoredox/Brønsted Acid Catalysis and Epimerization.
J. Am. Chem. Soc. 2023;
145: 2779-2786
DOI: 10.1021/jacs.2c12995.
Key words
iridium catalysis - enantioselectivity - diastereoselectivity - 3-substituted prolines - photoredox reaction
Significance
Peptides, including proline, are ubiquitous in biologically active molecules due to their unique structure. The Authors have developed a synthesis of diastereo- and enantioselective proline derivatives.
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Comment
The synthesis of proline derivatives was undergone by the help of iridium catalysis to afford various types of 3-substituted prolines in high to excellent yields with great diastereo- and enantioselectivity.
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Publication History
Article published online:
14 April 2023
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