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Synfacts 2022; 18(12): 1381
DOI: 10.1055/s-0042-1752352
DOI: 10.1055/s-0042-1752352
Peptide Chemistry
Photoredox Cobaloxime/Iridium Complex-Catalyzed Peptide-Bond Formation
Su J,
Mo J.-N,
Chen X,
Umanzor A,
Zhang Z,
Houk KN,
Zhao J.
*
Dalian University of Technology, P.R. of China
Generation of Oxyphosphonium Ions by Photoredox/Cobaloxime Catalysis for Scalable Amide and Peptide Synthesis in Batch and Continuous-Flow.
Angew. Chem. Int. Ed. 2022;
61: e202112668
DOI: 10.1002/anie.202112668
Generation of Oxyphosphonium Ions by Photoredox/Cobaloxime Catalysis for Scalable Amide and Peptide Synthesis in Batch and Continuous-Flow.
Angew. Chem. Int. Ed. 2022;
61: e202112668
DOI: 10.1002/anie.202112668
Key words
peptide bond formation - photoredox catalysis - cobaloxime catalysis - iridium catalysis - phosphines - flow reaction
Significance
Peptide bond formation is important in drug discovery and medicinal chemistry. The authors have developed a photoredox cobaloxime/iridium complex-catalyzed reaction to form peptide bonds under mild conditions with triphenylphosphine as a gentle reductant.
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Comment
Various examples of peptides, including dipeptides, tripeptides, and tetrapeptides were prepared in moderate to good yields under blue LED irradiation.
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Publication History
Article published online:
17 November 2022
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