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Synfacts 2023; 19(10): 1061
DOI: 10.1055/s-0042-1752186
DOI: 10.1055/s-0042-1752186
Peptide Chemistry
Ring-Opening of Aziridine Carboxylates for the Synthesis of Tryptophan Derivatives
Bennani YL,
Zhu G.-D,
Freeman JC.
Abbott Laboratories, Abbott Park, USA
Scandium-Mediated Opening of Aziridine Carboxylates: A Facile Synthesis of Aryl Substituted Tryptophans.
Synlett 1998; 754-756
DOI: 10.1055/s-1998-1773
Scandium-Mediated Opening of Aziridine Carboxylates: A Facile Synthesis of Aryl Substituted Tryptophans.
Synlett 1998; 754-756
DOI: 10.1055/s-1998-1773
Significance
Tryptophan and unnatural tryptophan derivatives are ubiquitous in many natural products and peptide drug molecules. In 1998, Bennani and co-workers developed a scandium-mediated ring-opening method of aziridine carboxylates for the synthesis of aryl-substituted tryptophan derivates.
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Comment
A series of aryl-substituted tryptophan derivates were synthesized with a scandium-mediated ring opening of aziridine carboxylates. This method is practically simple and synthesized various aryl-substituted tryptophan derivates in good yields.
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Publication History
Article published online:
14 September 2023
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