CC BY 4.0 · Aorta (Stamford) 2022; 10(S 01): A1-A56
DOI: 10.1055/s-0042-1750977
Presentation Abstracts

Thrombin-Antithrombin Complex Level in Patients with Abdominal Aortic Aneurysm and Peripheral Arterial Disease Undergoing Endovascular Interventions Predicts the Outcome of the Procedure

Michal Juszynski
1   Centre of Postgraduate Medical Education, Warsaw, Poland
,
Grzegorz Madycki
1   Centre of Postgraduate Medical Education, Warsaw, Poland
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    Objective: The level of activation of fibrinolytic system among patients with vascular disorders influences the course of their diseases as well as the results of operations and postoperative follow-up. While the activation of thrombin cannot be measured directly, because it connects with antithrombin forming the complex, Therefore, the assessment of thrombin–antithrombin (TAT) complex levels in the blood serum of that patients seems to be the reasonable method to estimate their susceptibility to postoperative complications.

    Methods: 60 patients were included in the study: 20 with AAA and 40 with PAD. Among patients with PAD: 20 were treated with PTA for the first time and 20 were treated with PTA due to the restenosis after PTA performed beforehand. 20 healthy volunteers were the control group. All the patients (and volunteers) had the sample of the blood collected in admission to the hospital and the level of the TAT complex was measured.

    Results: The mean levels of the TAT complexes in the blood serum among patients with AAA were 10,6 g/L. Therefore they were elevated more than twice above the norm (4,1 g/L). Patients with PAD admitted for the first-time PTA had the mean level of TAT complexes slightly elevated (mean4,8 g/L), but patients with PAD admitted to treat the postoperative complications (restenosis after PTA) had the levels of TAT complexes even higher than patients with AAA (mean 11.8 g/L). The levels of the TAT complexes among healthy volunteers didn’t exceed the norm (max.4 g/L).

    Conclusion: The measurement of the levels of the TAT complexes in the blood serum among the patients with vascular disorders seem to be the good method of assessment of the severity of their disease as well as their susceptibility to complications. The correlation between the thrombin - antithrombin complex levels and patients' susceptibility to complications after the endovascular interventions (which is the subject of our ongoing study) should reveal the predictive value of this method in the nearest future.


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    No conflict of interest has been declared by the author(s).

    Publication History

    Article published online:
    10 June 2022

    © 2022. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited. (https://creativecommons.org/licenses/by/4.0/)

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