SELF-EXPANDABLE METAL STENTS IN ESOPHAGEAL CANCER BEFORE PREOPERATIVE NEOADJUVANT THERAPY: EFFICACY, SAFETY AND LONG-TERM OUTCOMES

Aims Evaluate self-expandable metal stent (SEMS) placement impact on clinical and oncologic outcomes in patients with esophageal cancer who underwent surgery after neoadjuvant therapy (NT).

Methods Retrospective study of esophageal cancer patients referred for esophagectomy after NT. A propensity score was built consisting of the conditional probability of having had a SEMS given a set of baseline variables. In the SEMS group, patients underwent SEMS placement followed by NT and esophagectomy, whereas in the non-SEMS group, patients underwent only NT and esophagectomy.

Results One hundred patients were included, 29 in the SEMS group and 71 in the non-SEMS group. Median follow-up was 18 months. SEMS-related adverse events occurred in 20.7% of the patients. After propensity score analysis, SEMS use decreased delta dysphagia score (regression coefficient [RC]: – 2.69, 95% CI – 3.18 to – 2.21), dysphagia grade before surgery (RC: – 0.74, 95% CI – 1.22 to – 0.27), hospital readmissions at 1 month (OR 0.18; p=0.019), but increased overall morbidity after surgery (OR 3.02; p=0.045). No significant differences were found regarding delta albumin levels and albumin levels before surgery, delta weight and weight before surgery, death related to surgery, number of lymph nodes harvested, R0 resection rate, tumor recurrence, recurrence-free survival, overall survival, and 30-day, 6-month, and 3-year mortality.

Conclusions SEMS placement improved dysphagia and allowed patients to maintain an equal nutritional status compared to patients without dysphagia during NT. Although postsurgical morbidity was higher in patients with SEMS placement, postsurgical mortality and oncological outcome were not different.

 

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Publication History

Article published online:
14 April 2022