Planta Med 2017; 83(09): 797-804
DOI: 10.1055/s-0042-123708
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Triterpenoids with Antiplatelet Aggregation Activity from the Roots of Ilex pubescens

Qinglong Tan*
1   School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China
3   Second affiliation hospital, Guangzhou University of Chinese Medicine, Guangzhou, China
,
Maosong Qiu*
1   School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China
,
Di Cao
1   School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China
,
Tianqin Xiong
1   School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China
,
Lei Zhang
1   School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China
,
Lian Zhou
1   School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China
,
Li Rong
1   School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China
,
Jinsong Zhou
1   School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China
,
Jing Jin
2   School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, China
,
Zhongxiang Zhao
1   School of Chinese Materia medica, Guangzhou University of Chinese Medicine, Guangzhou, China
› Institutsangaben
Weitere Informationen

Publikationsverlauf

received 10. September 2016
revised 03. Dezember 2016

accepted 08. Dezember 2016

Publikationsdatum:
22. Dezember 2016 (online)

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Abstract

Two new triterpenes and five new triterpene saponins, named ilexpusons A–G (17), as well as eight known compounds were isolated from Ilex pubescens. The structures of the new compounds were established by a combination of chemical and spectroscopic methods, including HRESIMS, 1H-NMR, 13C-NMR, 1H-1H COSY, HSQC, HMBC, and NOESY. Additionally, the biological activity of compounds 1 – 15 against adenosine diphosphate-induced platelet aggregation in rabbit plasma was determined. Among the tested compounds, 1, 2, 5, 6, 8, 13, 14, and 15 exhibited significant inhibition of platelet aggregation in vitro.

* Co-first authors.


Supporting Information

Spectroscopic data of compounds 17 and the dose-response curves of the active compounds are available as Supporting Information.