Colonoscopy is the preferred diagnostic and therapeutic modality in the lower intestinal
tract. Most Dutch hospitals use Lefax (Bayer Vital GmbH, Leverkusen, Germany) to optimize
endoscopic imaging. The main component of Lefax is simethicone ([Fig. 1]), a silicon dioxide crystalloid of the silicone polymer dimethicone, which decreases
the surface tension of bubbles. Lefax is added to water and injected via the waterjet
channel of the colonoscope to create a powerful and directional beam.
Fig. 1 Chemical structure of simethicone, as used in Lefax.
Recently, a waterjet channel connector ([Fig. 2]) broke off a colonoscope (Fujinon EC-590 WL; Fujifilm Corporation, Tokyo, Japan)
in our department. During repair, crystalline deposits were noticed inside the connector
([Fig. 3]). Closer examination revealed deposits in every component within the channel ([Fig. 4]). Infrared spectral analysis by our clinical pharmacy laboratory showed that the
crystals consisted of dimethicone ([Fig. 5 a, b]).
Fig. 2 The colonoscope waterjet connector where crystal deposits were observed.
Fig. 3 Crystal deposits within the connector.
Fig. 4 Crystal deposits within the waterjet channel (tube cut open) (arrows).
Fig. 5 a, b Result of the infrared spectral analysis, showing the presence of dimethicone.
A total of 16 colonoscopies are used in our department. All of them are Fujinon scopes,
from the series EC-530 WI-H (n = 1), EC-590 WL (n = 3), EC-590 WL4 (n = 3), and EC-600
WL (n = 9), and all had crystal deposits.
Crystals could only be seen by thorough inspection, not during regular checkups. Elimination
of the crystals was only possible by mechanical cleaning after the connector had been
removed and the channel opened. Repeated attempts at washing with (warm) water, peracetic
acid, and precleaning detergent (Neodisher SC; Dr Weigert, Mühlenhagen, Hamburg, Germany)
were unsuccessful. As the connector has a 90° angle and the waterjet channel is only
1.2 mm in diameter, this channel can only be cleaned by flushing, not by mechanical
means. Crystal deposits may therefore eventually lead to occlusion of the waterjet
channel. When deposits remain, flushing may no longer be effective for cleaning, increasing
the risk of microbiological film formation and patient contamination. No such cases
have yet been seen in our department.
The presence of dimethicone crystal deposits in colonoscope waterjet channels has
potentially important clinical consequences. Simethicone is used in many endoscopy
departments, both within and outside the Netherlands, and no alternative product with
the same properties is available. It must be stressed that the use of Lefax in colonoscope
waterjet channels is off-label; according to the manufacturer only water should be
used.
Following this discovery Lefax has only been used via the colonoscope working channel
in our department, leading to less than optimal focal cleansing. It is important that
endoscopy units outside the Netherlands are informed about these findings, which have
not been reported previously.
Endoscopy_UCTN_Code_CPL_1AN_2AF
