Zentralbl Chir 2017; 142(03): 306-311
DOI: 10.1055/s-0042-109977
Übersicht
Georg Thieme Verlag KG Stuttgart · New York

Rezidivprophylaxe des Ulcus cruris venosum

Prophylaxis of Recurrent Venous Leg Ulcer
K. Kroeger
1   Angiologie, HELIOS Kliniken Krefeld, Deutschland
,
M. Storck
2   Gefäßzentrum Karlsruhe, Städt. Klinikum Karlsruhe, Deutschland
,
P. Kujath
3   Klinik für Chirurgie, Universitätsklinikum Schleswig-Holstein, Lübeck, Deutschland
,
E. Rabe
4   Klinik für Dermatologie, Universitätsklinik Bonn, Deutschland
,
J. Dissemond
5   Klinik für Dermatologie, Universitätsklinik Essen, Deutschland
› Author Affiliations
Further Information

Publication History

Publication Date:
08 August 2016 (online)

Zusammenfassung

Das Ulcus cruris venosum (UCV) ist in Europa eine der häufigsten chronischen Wunden. Die Therapie ist langwierig, mühsam und kostenintensiv, und es besteht eine hohe Rezidivquote. In diesem Beitrag werden die Maßnahmen dargestellt, die jedem Patienten mit abgeheiltem UCV angeboten werden sollten, um das Auftreten eines erneuten UCV dauerhaft zu verhindern. Um einem UCV bei Varikose vorzubeugen, muss die Progression der chronischen venösen Insuffizienz (CVI) gestoppt werden. Es existiert eine überzeugende Evidenz dazu, dass die effiziente Therapie der Varikose bei Patienten mit UCV die Rezidivrate senkt. Bei Patienten mit einem postthrombotischen Syndrom (PTS) sollten weitere Thrombosen durch eine gezielte Thromboseprophylaxe verhindert werden. Für den Nutzen endovaskulärer rekanalisierender Verfahren bei Patienten mit postthrombotischen Veränderungen der Beckenvenen auf die Rezidivrate des UCV gibt es bisher keine Studien. Für UCV bei Varikose und PTS wurde in mehreren Studien eindrücklich gezeigt, dass die Kompressionstherapie die Basismaßnahme für die Prävention eines Ulkusrezidivs ist, unabhängig davon, ob andere Maßnahmen durchgeführt wurden oder nicht. Wichtiger als eine möglichst hohe Kompressionsklasse ist eine gute Adhärenz der betroffenen Patienten bei der Kompressionstherapie. Das Ziel zukünftiger Bemühungen für Patienten mit UCV muss es sein, den Therapeuten Instrumente und Behandlungsstrategien an die Hand zu geben, den Patienten zu führen und dessen Akzeptanz und Verständnis für die Bedeutung des Selbstmanagements insbesondere der Kompressionstherapie für die Rezidivprophylaxe zu erhöhen.

Abstract

Venous leg ulcer (VLU) counts among the most common chronic wounds in Europe. Treatment is lengthy, cumbersome and costly, and there is a high rate of recurrence. This review shows the measures that should be offered to every patient with healed VLU to permanently prevent recurrence. To prevent VLU in case of varicose veins, the progression of chronic venous insufficiency (CVI) has to be stopped. There is convincing evidence that the effective treatment of varicose veins reduces the recurrence rate in patients with VLU. In patients with post-thrombotic syndrome (PTS), further thrombosis should be prevented through targeted prophylaxis of new thromboembolic events. The benefit of endovascular revascularization on the VLU recurrence rate in patients with post-thrombotic damage in the pelvic veins has not been proven in clinical studies. On the other hand, it has been clearly demonstrated in several studies that compression therapy is the basic procedure for the prevention of recurrent VLU in patients with varicose veins or PTS, regardless of whether other measures have been implemented or not. Good adherence in patients with compression therapy is more important than choosing the highest possible compression class. Future efforts for patients with VLU must aim to provide therapists with tools and treatment strategies to guide their patients and to increase patientsʼ acceptance and understanding of the importance of self-management, in particular regarding compression therapy for the prevention of recurrent VLU.

 
  • Literatur

  • 1 Sauer K, Kemper C, Schulze J, Glaeske G. BARMER GEK Heil- und Hilfsmittelreport. 2013
  • 2 Purwins S, Herberger K, Debus ES. et al. Cost-of-illness of chronic leg ulcers in Germany. Int Wound J 2010; 7: 97-102
  • 3 Augustin M, Brocatti LK, Rustenbach SJ. et al. Cost-of-illness of leg ulcers in the community. Int Wound J 2014; 11: 283-292
  • 4 Rabe E, Pannier-Fischer F, Bromen K. et al. Bonner Venenstudie. Epidemiologische Untersuchung zur Frage der Häufigkeit und Ausprägung der chronischen Venenkrankheit in der städtischen und ländlichen Wohnbevölkerung. Phlebologie 2003; 32: 1-14
  • 5 Campbell B. New evidence on treatments for varicose veins. Br J Surg 2014; 101: 1037-1039
  • 6 Kluess HG, Noppeney T, Breu FX. et al. Leitlinie zur Diagnostik und Therapie der Krampfadererkrankung der Deutschen Gesellschaft für Phlebologie, der Deutschen Gesellschaft für Gefäßchirurgie, des Berufsverbandes der Phlebologen e.V. und der Arbeitsgemeinschaft der niedergelassenen Gefäßchirurgen Deutschlands e.V. Phlebologie 2010; 39: 271-289
  • 7 Howard DP, Howard A, Kothari A. et al. The role of superficial venous surgery in the management of venous ulcers: a systematic review. Eur J Vasc Endovasc Surg 2008; 36: 458-465
  • 8 Gohel MS, Barwell JR, Taylor M. et al. Long term results of compression therapy alone versus compression plus surgery in chronic venous ulceration (ESCHAR): randomised controlled trial. BMJ 2007; 335: 83
  • 9 Kulkarni SR, Slim FJ, Emerson LG. et al. Effect of foam sclerotherapy on healing and long-term recurrence in chronic venous leg ulcers. Phlebology 2013; 28: 140-146
  • 10 Alden PB, Lips EM, Zimmerman KP. et al. Chronic venous ulcer: minimally invasive treatment of superficial axial and perforator vein reflux speeds healing and reduces recurrence. Ann Vasc Surg 2013; 27: 75-83
  • 11 Carroll C, Hummel S, Leaviss J. et al. Clinical effectiveness and cost-effectiveness of minimally invasive techniques to manage varicose veins: a systematic review and economic evaluation. Health Technol Assess 2013; 17: 1-141 DOI: 10.3310/hta17480
  • 12 De Wolf MA, de Graaf R, Kurstjens RL. et al. Short-term clinical experience with a dedicated venous nitinol stent: Initial results with the sinus-venous stent. Eur J Vasc Endovasc Surg 2015; 50: 518-526
  • 13 Alhalbouni S, Hingorani A, Shiferson A. et al. Iliac-femoral venous stenting for lower extremity venous stasis symptoms. Ann Vasc Surg 2012; 26: 185-189
  • 14 Raju S. Best management options for chronic iliac vein stenosis or occlusion. J Vasc Surg 2013; 57: 1163-1169
  • 15 van Gent WB, Hop WC, van Praag MC. et al. Conservative versus surgical treatment of venous leg ulcers: a prospective, randomized, multicenter trial. J Vasc Surg 2006; 44: 563-571
  • 16 Nelson EA, Bell-Syer SE. Compression for preventing recurrence of venous ulcers. Cochrane Database Syst Rev 2014; (09) CD002303
  • 17 Vandongen YK, Stacey MC. Graduated compression elastic stockings reduce lipodermatosclerosis and ulcer recurrence. Phlebology 2000; 15: 33-37
  • 18 Rabe E, Partsch H, Jünger M. et al. Guidelines for clinical studies with compression devices in patients with venous disorders of the lower limb. Eur J Vasc Endovasc Surg 2008; 35: 494-500
  • 19 Harper DR, Nelson EA, Gibson B. et al. A prospective, controlled, randomized trial of class 2 and class 3 elastic compression in the prevention of venous ulceration. Proceedings of the 5th European Conference on Advances in Wound Management. London: Macmillan Magazines; 1996: 55
  • 20 Milic DJ, Zivic SS, Bogdanovic DC. et al. A randomized trial of class 2 and class 3 elastic compression in the prevention of recurrence of venous ulceration. J Vasc Surg 2010; 51: 797-798
  • 21 Franks PJ, Oldroyd MI, Dickson D. et al. Risk factors for leg ulcer recurrence: A randomized trial of two types of compression stocking. Age Ageing 1995; 24: 490-494
  • 22 Kapp S, Miller C, Donohue L. The clinical effectiveness of two compression stocking treatments on venous leg ulcer recurrence: a randomized controlled trial. Int J Low Extrem Wounds 2013; 12: 189-198
  • 23 Clarke-Moloney M, Keane N, OʼConnor V. et al. Randomised controlled trial comparing European standard class 1 to class 2 compression stockings for ulcer recurrence and patient compliance. Int Wound J 2014; 11: 404-408
  • 24 Moffatt C, Kommala D, Dourdin N. et al. Venous leg ulcers: patient concordance with compression therapy and its impact on healing and prevention of recurrence. Int Wound J 2009; 6: 386-393
  • 25 Shannon MM, Hawk J, Navaroli L. et al. Factors affecting patient adherence to recommended measures for prevention of recurrent venous ulcers. J Wound Ostomy Continence Nurs 2013; 40: 268-274
  • 26 McNichol E. Involving patients with leg ulcers in developing innovations in treatment and management strategies. Br J Community Nurs 2014; Suppl. S27-S28 S30–S32
  • 27 Woo KY, Alavi A, Evans R. et al. New advances in compression therapy for venous leg ulcers. Surg Technol Int 2013; 23: 61-68
  • 28 Bainbridge P. Why donʼt patients adhere to compression therapy?. Br J Community Nurs 2013; Suppl. S35-S40
  • 29 Weller CD, Buchbinder R, Johnston RV. Interventions for helping people adhere to compression treatments for venous leg ulceration. Cochrane Database Syst Rev 2013; (09) CD008378
  • 30 Sippel K, Seifert B, Hafner J. Donning devices (foot slips and frames) enable elderly people with severe chronic venous insufficiency to put on compression stockings. Eur J Vasc Endovasc Surg 2015; 49: 221-229
  • 31 Finlayson K, Edwards H, Courtney M. Relationships between preventive activities, psychosocial factors and recurrence of venous leg ulcers: a prospective study. J Adv Nurs 2011; 67: 2180-2190
  • 32 Finlayson K, Wu ML, Edwards HE. Identifying risk factors and protective factors for venous leg ulcer recurrence using a theoretical approach: a longitudinal study. Int J Nurs Stud 2015; 52: 1042-1051
  • 33 Brown A. Life-style advice and self-care strategies for venous leg ulcer patients: what is the evidence?. J Wound Care 2012; 21: 342-344
  • 34 Klyscz T, Jünger M, Jünger I. et al. [Vascular sports in ambulatory therapy of venous circulatory disorders of the legs. Diagnostic, therapeutic and prognostic aspects]. Hautarzt 1997; 48: 384-390
  • 35 Kapp S, Miller C. The experience of self-management following venous leg ulcer healing. J Clin Nurs 2015; 24: 1300-1309
  • 36 OʼBrien JA, Finlayson KJ, Kerr G. et al. Testing the effectiveness of a self-efficacy based exercise intervention for adults with venous leg ulcers: protocol of a randomised controlled trial. BMC Dermatol 2014; 3: 14-16
  • 37 Neumann M, Cornu-Thénard A, Jünger M. et al. Evidence based (S3) guidelines for diagnostics and treatment of venous leg ulcers. Im Internet: http://www.euroderm.org/edf/index.php/edf-guidelines/category/5-guidelines-miscellaneous?download=22:guideline-diagnostics-and-treatment-of-venous-leg-ulcers-update-2014 Stand: 22.03.2016
  • 38 Lawson JA, Toonder IM. A review of a new Dutch guideline for management of recurrent varicose veins. Phlebology 2016; 31 (Suppl. 01) S114-S124
  • 39 OʼDonnell jr. TF, Balk EM. The need for an Intersociety Consensus Guideline for venous ulcer. J Vasc Surg 2011; 54 (Suppl. 06) S83-S90