Prostatakarzinom imitiert metastasiertes Bronchialkarzinom – Ein Fallbericht

Zusammenfassung

Es wird über den Fall eines PSA-negativen und lokal fortgeschrittenen azinären Prostatakarzinoms berichtet, das bei thyroid transcription factor-1 (TTF-1) Expression eine Metastase eines bereits behandelten Bronchialkarzinoms imitierte. Unseres Wissens ist ein TTF-1 positiv azinäres Prostatakarzinom bisher nur ein Mal in der Literatur dokumentiert. Die Bestimmung des Immunophänotyps des Karzinoms mit Napsin A, CK7 und CK20 in Kombination mit der Beurteilung des gesamten Krankheitsverhaltens waren für die definitive Diagnose eines primären Prostatakarzinoms entscheidend.

Abstract

A PSA-negative, advanced adenocarcinoma of the prostate is a rare finding. Expression of thyroid transcription factor-1 (TTF-1) in the tumour in combination with a previous medical history of lung adenocarcinoma could complicate the final diagnosis. To the best of our knowledge, we present the second case of a TTF-1-positive, acinar adenocarcinoma of the prostate.

We present the case of a 65-year-old male with surgically treated lung adenocarcinoma; 3 years later we diagnosed adenocarcinoma of the bladder and prostate. Although our initial assumption was that the patient had metastatic lung carcinoma in the bladder and prostate, a further immune histochemical analysis of the carcinoma with Napsin A, CK7 and CK20, along with the evaluation of the clinical manifestations, led us to the diagnosis of primary adenocarcinoma of the prostate.

Schlüsselwörter

PSA-negatives Prostatakarzinom - TTF-1 Expression - Bronchialkarzinom - Napsin A - CK7 - CK20

Key words

PSA-negative adenocarcinoma of the prostate - TTF-1 expression - lung adenocarcinoma - Napsin A - CK7 - CK20

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