Peniphenylanes A–G from the Deep-Sea-Derived Fungus Penicillium fellutanum HDN14-323

Zhenzhen Zhang; Wenqiang Guo; Xueqian He; Qian Che; Tianjiao Zhu; Qianqun Gu; Dehai Li

doi:10.1055/s-0042-102885

Planta Medica, Table of Contents

Planta Med 2016; 82(09/10): 872-876
DOI: 10.1055/s-0042-102885

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Peniphenylanes A–G from the Deep-Sea-Derived Fungus Penicillium fellutanum HDN14-323

Authors

Zhenzhen Zhang

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
Wenqiang Guo

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
Xueqian He

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
Qian Che

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
Tianjiao Zhu

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
Qianqun Gu

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China
Dehai Li

Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, P. R. China

Abstract

Seven new 6-methylsaligenin derivatives, including the trimeric peniphenylanes A–B (1–2) and dimeric peniphenylanes C–G (3–7), together with four known biogenetically related compounds (8–11) were discovered from the extract of the deep-sea-derived fungus Penicillium fellutanum HDN14-323. The structures of the new compounds were established through extensive analysis. Their cytotoxic activity against HeLa, HL-60, and HCT-116 cell lines was evaluated, with compound 4 exhibiting the best activity against the HeLa cell line (IC₅₀ = 9.3 µM).

Key words

Penicillium fellutanum - Trichocomaceae - 6-methylsaligenin - peniphenylanes - deep-sea-derived fungus - cytotoxic activity

Full Text

References

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