Bishnu P. Joshi et al. Multimodal endoscope can quantify wide-field fluorescence detection
of Barrett’s neoplasia
Molecular endoscopy is an evolving technology for evaluation of preneoplastic lesions
such as Barrett’s esophagus. In this study from the USA, the authors used a multimodal
endoscope with a targeted fluorescent peptide for quantitative detection of neoplasia
in 50 patients with Barrett’s esophagus. Early neoplasia was identified with 76% sensitivity,
94% specificity, and a positive predictive value of 96%. The authors conclude that
a multimodal endoscope seems to offer an improved method for the early detection of
neoplasia in the esophagus and other epithelial-derived cancers, which are often flat
in appearance, patchy in distribution, and difficult to visualize with white-light
endoscopy alone.
