Planta Med 2016; 82(08): 723-728
DOI: 10.1055/s-0042-100915
Natural Product Chemistry and Analytical Studies
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Polycyclic Spiro Lignans and Biphenyl Tetrahydrofuranone Lignans from Gymnotheca involucrata

Shi-Ji Xiao
1   Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, P. R. China
2   School of Pharmacy, Zunyi Medical University, Zunyi, P. R. China
,
Da-Le Guo
1   Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, P. R. China
,
Bing Xia
1   Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, P. R. China
,
Sarah Allen
3   Syngenta Jealottʼs Hill International Research Centre, Berkshire, United Kingdom
,
Yu-Cheng Gu
3   Syngenta Jealottʼs Hill International Research Centre, Berkshire, United Kingdom
,
Fang Chen
4   College of Life Sciences, Sichuan University, Chengdu, P. R. China
,
Li-Sheng Ding
1   Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, P. R. China
,
Yan Zhou
1   Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, P. R. China
› Author Affiliations
Further Information

Publication History

received 13 October 2015
revised 01 December 2015

accepted 22 December 2015

Publication Date:
12 February 2016 (online)

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Abstract

Four rare polycyclic spiro lignans (14) and four new biphenyl tetrahydrofuranone lignans (58) were isolated from the whole plant of Gymnotheca involucrata. The structures of the new compounds were elucidated on the basis of detailed spectroscopic analysis and the absolute configuration of 1 was confirmed by single crystal X-ray diffraction. Bioassay results showed that compounds 2 and 6 exhibited weak antifungal activity against Uromyces viciae-fabae at 100 ppm in leaf-disc assays, while compound 3 demonstrated moderate insecticidal activity against Diabrotica balteata at 500 ppm in an artificial diet assay.

Supporting Information