Zheng Y.-X,
Jiao L.
*
Tsinghua University, Beijing, P. R. of China
Hybrid Cycloolefin Ligands for Palladium–Olefin Cooperative Catalysis.
Nat. Synth. 2022;
1: 180-187
DOI:
10.1038/S44160-021-00019-8
Key words
alkene ligands - Catellani reaction - dithiane - palladium catalysis
Significance
A new ligand design for cooperative palladium–olefin catalysis is disclosed. The combination
of an unstrained cycloolefin ligand with a dithiane donor enables palladium-catalyzed
Catellani-type reactions with unprecedented reactivity without the need for the norbornene
scaffold.
Comment
Various alkyl iodides were employed as coupling partners, demonstrating the broad
functional group tolerance of this method. The reaction can be terminated by a Heck
reaction or by cross-coupling with organometallic reagents, resulting in vicinal difunctionalization
of the aryl iodide.
