Subscribe to RSS
Please copy the URL and add it into your RSS Feed Reader.
https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml
Synfacts 2022; 18(07): 0749
DOI: 10.1055/s-0041-1737613
DOI: 10.1055/s-0041-1737613
Metals in Synthesis
Photoinduced Cobalt-Catalyzed Enantioselective Reductive Addition of Aryl Iodides to Aldehydes
Jiang X,
Jiang H,
Yang Q,
Cheng Y,
Lu L.-Q,
*,
Tunge JA,
Xiao W.-J.
*
Central China Normal University, Wuhan, Lanzhou Institute of Chemical Physics (LICP), Henan Normal University, Xinxiang, and Lanzhou University, P. R. of China
Photoassisted Cobalt-Catalyzed Asymmetric Reductive Grignard-Type Addition of Aryl Iodides.
J. Am. Chem. Soc. 2022;
144: 8347-8354
DOI: 10.1021/jacs.2c02481.
Photoassisted Cobalt-Catalyzed Asymmetric Reductive Grignard-Type Addition of Aryl Iodides.
J. Am. Chem. Soc. 2022;
144: 8347-8354
DOI: 10.1021/jacs.2c02481.
Key words
cobalt catalysis - photoredox catalysis - Hantzsch esters - asymmetric reaction - Grignard-type addition
Significance
A photoredox cobalt-catalyzed enantioselective approach to a Grignard-type addition of aryl iodides to aldehydes is reported. Notably, the mild reaction conditions enable a wide range of functional groups and heterocycles to be tolerated.
#
Comment
4CzIPN is used as the photocatalyst, which can be excited under visible-light irradiation. The use of Hantzsch ester as the reductant is notable because it avoids the generation of stoichiometric metal waste.
#
#
Publication History
Article published online:
15 June 2022
© 2022. Thieme. All rights reserved
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany