Download PDF
Synfacts 2022; 18(07): 0749
DOI: 10.1055/s-0041-1737613
Metals in Synthesis

Photoinduced Cobalt-Catalyzed Enantioselective Reductive Addition of Aryl Iodides to Aldehydes

Authors

    Contributor(s):

  • Mark Lautens

  • Jeanne Masson-Makdissi

Jiang X, Jiang H, Yang Q, Cheng Y, Lu L.-Q, *, Tunge JA, Xiao W.-J. * Central China Normal University, Wuhan, Lanzhou Institute of Chemical Physics (LICP), Henan Normal University, Xinxiang, and Lanzhou University, P. R. of China
Photoassisted Cobalt-Catalyzed Asymmetric Reductive Grignard-Type Addition of Aryl Iodides.

J. Am. Chem. Soc. 2022;
144: 8347-8354
DOI: 10.1021/jacs.2c02481
CrossrefPubMedSearch in Google Scholar
Further Information
 
 PDF Download Permissions and Reprints

Key words

cobalt catalysis - photoredox catalysis - Hantzsch esters - asymmetric reaction - Grignard-type addition

Significance

A photoredox cobalt-catalyzed ­enantioselective approach to a Grignard-type addition of aryl iodides to aldehydes is reported. Notably, the mild reaction conditions enable a wide range of functional groups and heterocycles to be tolerated.


 

Comment

4CzIPN is used as the photocatalyst, which can be excited under visible-light irradiation. The use of Hantzsch ester as the reductant is notable because it avoids the generation of stoichiometric metal waste.


 

 

Publication History

Article published online:
15 June 2022

© 2022. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany


  Permissions and Reprints