Homœopathic Links 2021; 34(02): 112-118
DOI: 10.1055/s-0041-1732782
Review Article

Introspecting Scope of Ultra-Diluted Homeopathic Preparations in Human SARS-CoV-2 Infection: A Perspective Review

Abhishek Das
1   Department of Microbiology, St. Paul's Cathedral Mission College, University of Calcutta, Kolkata, West Bengal, India
,
Shubhamoy Ghosh
2   Department of Pathology & Microbiology, Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Howrah, West Bengal, India
,
Satadal Das
3   Peerless Hospital & B.K. Roy Research Centre, Kolkata, West Bengal, India
,
Sudip Kumar Das
4   Chemical Engineering Department, University of Calcutta, Kolkata, West Bengal, India
,
Sayak Ghosh
5   Department of Medicine, The Calcutta Homeopathic Medical College and Hospital, Kolkata, West Bengal, India
,
6   Department of Organon of Medicine, National Institute of Homeopathy, Kolkata (under Ministry of AYUSH, Govt. of India), Kolkata, West Bengal, India
,
7   Department of Medicine, Mahesh Bhattacharyya Homoeopathic Medical College and Hospital, Howrah, West Bengal, India
› Author Affiliations

Abstract

Coronavirus disease 2019 (COVID-19) is a zoonotic disease caused by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). Its symptoms range from mild fever, cough, pharyngitis to severe acute respiratory syndrome. Since its first outbreak in Wuhan province of China, the disease has spread worldwide and emerged as pandemic. The infection is mainly spread by droplets and through contacts. Initially SARS-CoV-2 was thought to cause viral pneumonia only, but now it is evident that the virus can spread through the bloodstream and can cause systemic lesions as well. Though most of the time patients recovered spontaneously for immune-compromised patients, it is detrimental. Lack of effective therapy in conventional medicine has made host immune response as the only option to focus on this battle against COVID-19. First-world countries such as the USA, Italy, England and Spain have witnessed a massive number of deaths, and India is not an exception to that. The whole world is searching for effective treatment in the form of antiviral drugs, vaccines and hydroxychloroquine, but none has proven effective. Homeopathy has always put a mark during epidemics and in recent past during the elimination of leptospirosis in Cuba (2009–2014), homeopathy was very effective. In this scenario, we think homeopathy has a decisive role to play to fight this pandemic as it can enhance the host immune response and reduce the severity of the infection to a great extent. In this review, we will discuss the scopes of homeopathic medicines in the treatment of coronavirus disease.



Publication History

Article published online:
07 July 2021

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  • Reference

  • 1 Zhong NS, Zheng BJ, Li YM. et al. Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003. Lancet 2003; 362 (9393): 1353-1358
  • 2 World Health Organization, health topics [Internet], WHO. [cited 2020 Feb 26]. Available from: http://www.emro.who.int/health-topics/. Accessed Sep 29, 2020
  • 3 Hu D, Zhu C, Ai L. et al. Genomic characterization and infectivity of a novel SARS-like coronavirus in Chinese bats. Emerg Microbes Infect 2018; 7 (01) 154
  • 4 Chan JF, Yuan S, Kok KH. et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet 2020; 395 (10223): 514-523
  • 5 Thompson R. Pandemic potential of 2019-nCoV. Lancet Infect Dis 2020; 20 (03) 280
  • 6 Baud D, Qi X, Nielsen-Saines K, Musso D, Pomar L, Favre G. Real estimates of mortality following COVID-19 infection. Lancet Infect Dis 2020; 20 (07) 773
  • 7 Li F. Structure, function, and evolution of coronavirus spike proteins. Annu Rev Virol 2016; 3 (01) 237-261
  • 8 Bracho G, Varela E, Fernández R. et al. Large-scale application of highly-diluted bacteria for Leptospirosis epidemic control. Homeopathy 2010; 99 (03) 156-166
  • 9 Zhou F, Yu T, Du R. et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020; 395 (10229): 1054-1062
  • 10 Cao B, Wang Y, Wen D. et al. A trial of Lopinavir-ritonavir in adults hospitalized with severe Covid-19. N Engl J Med 2020; 382 (19) 1787-1799
  • 11 Gautret P, Lagier JC, Parola P. et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents 2020; 56 (01) 105949
  • 12 Medscape.com. 2020 . What Is the Global and US Prevalence of Coronavirus Disease 2019 (COVID-19)? [online] Available at: https://www.medscape.com/answers/2500114-197405/what-is-the-global-and-us-prevalence-of-coronavirus-disease-2019-covid-19#qna. Accessed Sep 1, 2020
  • 13 Fehr AR, Perlman S. Coronaviruses: an overview of their replication and pathogenesis. Methods Mol Biol 2015; 1282: 1-23
  • 14 Ortega JT, Serrano ML, Pujol FH, Rangel HR. Role of changes in SARS-CoV-2 spike protein in the interaction with the human ACE2 receptor: an in silico analysis. EXCLI J 2020; 19: 410-417
  • 15 Boopathi S, Poma AB, Kolandaivel P. Novel 2019 coronavirus structure, mechanism of action, antiviral drug promises and rule out against its treatment. J Biomol Struct Dyn 2020 [published online ahead of print, 2020 Apr 30]
  • 16 Posthuma CC, Te Velthuis AJW, Snijder EJ. Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes. Virus Res 2017; 234: 58-73
  • 17 Channappanavar R, Zhao J, Perlman S. T cell-mediated immune response to respiratory coronaviruses. Immunol Res 2014; 59 (1-3): 118-128
  • 18 Chen Y, Guo Y, Pan Y, Zhao ZJ. Structure analysis of the receptor binding of 2019-nCoV. Biochem Biophys Res Commun 2020; 525: 135-140
  • 19 Walls AC, Park YJ, Tortorici MA, Wall A, McGuire AT, Veesler D. Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell 2020; 181 (02) 281-292.e6
  • 20 Letko M, Marzi A, Munster V. Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B beta coronaviruses. Nat Microbiol 2020; 5 (04) 562-569
  • 21 Zou X, Chen K, Zou J, Han P, Hao J, Han Z. Single-cell RNA-seq data analysis on the receptor ACE2 expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection. Front Med 2020; 14 (02) 185-192
  • 22 Belouzard S, Millet JK, Licitra BN, Whittaker GR. Mechanisms of coronavirus cell entry mediated by the viral spike protein. Viruses 2012; 4 (06) 1011-1033
  • 23 Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol 2004; 203 (02) 631-637
  • 24 Jia HP, Look DC, Shi L. et al. ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J Virol 2005; 79 (23) 14614-14621
  • 25 Zhou Y, Fu B, Zheng X. et al. Pathogenic T cells and inflammatory monocytes incite inflammatory storm in severeCOVID-19 patients. Nat Med 2018; 24 (06) 731-738
  • 26 Qin C, Zhou L, Hu Z. et al. Dysregulation of immune response in patients with coronavirus 2019 (COVID-19) in Wuhan, China. Clin Infect Dis 2020; 71 (15) 762-768
  • 27 Young RE, Thompson RD, Larbi KY. et al. Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo. J Immunol 2004; 172 (07) 4493-4502
  • 28 Liu S, Su X, Pan P. et al. Neutrophil extracellular traps are indirectly triggered by lipopolysaccharide and contribute to acute lung injury. Sci Rep 2016; 6: 37252
  • 29 Koutsogiannaki S, Shimaoka M, Yuki K. The use of volatile anesthetics as sedatives for acute respiratory distress syndrome. Transl Perioper Pain Med 2019; 6 (02) 27-38
  • 30 Guan WJ, Ni ZY, Hu Y. et al. Clinical characteristics of 2019 novel coronavirus infection in China. N Engl J Med 2020; 382 (18) 1708-1720
  • 31 Bellavite P, Conforti A, Pontarollo F, Ortolani R. Immunology and homeopathy. 2. Cells of the immune system and inflammation. Evid Based Complement Alternat Med 2006; 3 (01) 13-24
  • 32 Yuki K, Fujiogi M, Koutsogiannaki S. COVID-19 pathophysiology: a review. Clin Immunol 2020; 215: 108427
  • 33 Mathie RT, Baitson ES, Frye J, Nayak C, Manchanda RK, Fisher P. Homeopathic treatment of patients with influenza-like illness during the 2009 A/H1N1 influenza pandemic in India. Homeopathy 2013; 102 (03) 187-192
  • 34 Chakraborty PS, Lamba CD, Nayak D. et al. Effect of individualized homoeopathic treatment in influenza like illness: a multicenter, single blind, randomized, placebo-controlled study. Indian Journal of Research in Homoeopathy. 2013; 7 (01) 22-30
  • 35 Borland DM. Pneumonias. New Delhi; B Jain Publishers: 2013: 30-59
  • 36 de Oliveira CC, Abud AP, de Oliveira SM. et al. Developments on drug discovery and on new therapeutics: highly diluted tinctures act as biological response modifiers. BMC Complement Altern Med 2011; 11 (01) 101
  • 37 Jeanne M, Lallemand-Breitenbach V, Ferhi O. et al. PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3. Cancer Cell 2010; 18 (01) 88-98
  • 38 HadiGhaffari. et al. Inhibition of H1N1 influenza virus infection by zinc oxide nanoparticles: another emerging application of nanomedicine. J Biomed Sci 2019; 26 (01) 1-10
  • 39 Lo-Coco F, Avvisati G, Vignetti M. Gruppo Italiano Malattie Ematologiche dell'Adulto, German-Austrian Acute Myeloid Leukemia Study Group, Study Alliance Leukemia. et al; Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med 2013; 369 (02) 111-121
  • 40 Sánchez Y, Amrán D, de Blas E, Aller P. Arsenic trioxide as an anti-tumour agent: mechanisms of action and strategies of sensitization. J Appl Biomed 2010; 8: 199-208
  • 41 Jacobs J. Homeopathic prevention and management of epidemic diseases. Homeopathy 2018; 107 (03) 157-160
  • 42 Hahnemann S. Organon of Medicine. 5th edition.. New Delhi: B Jain Publishers; 2002
  • 43 Mathie RT, Frye J, Fisher P. Homeopathic Oscillococcinum® for preventing and treating influenza and influenza-like illness. Cochrane Database Syst Rev 2015; 1 (01) CD001957
  • 44 Coronavirus COVID. . – 19–Society of Homeopaths [Internet]. [cited 2020 May 16]. Available from: https://homeopathy-soh.org/coronavirus-covid-19/. Accessed Sep 29, 2020
  • 45 Coronavirus – Advice from the UK Homeopathic Community [Internet], The Faculty of Homeopathy. 2020 [cited 2020 May 16]. Available from: https://facultyofhomeopathy.org/coronavirus-advice-from-the-uk-homeopathic-community/. Accessed Sep 29, 2020
  • 46 Beghi GM, Morselli-Labate AM. Does homeopathic medicine have a preventive effect on respiratory tract infections? A real life observational study. Multidiscip Respir Med 2016; 11: 12
  • 47 Harilal KN, Thyagaraj AP, Thomas MV, Suresh AT. Development of Homoeopathic Genus Epidemicus for Secondary Level Prevention of Dengue Virus Infection at Kannur, Kerala. Available from: https://www.researchgate.net/publication/326742719 Accessed Sep 29, 2020
  • 48 Pal P, Ningthoujam G. Research review of genus Epidemicus. International Journal of Advanced Ayurveda, Yoga, Unani. Siddha and Homeopathy. 2019; 8 (01) 545-550
  • 49 Q&A on coronaviruses (COVID-19) [Internet]. [cited 2020 May 15]. . Available from: https://www.who.int/news-room/q-a-detail/q-a-coronaviruses. Accessed Sep 29, 2020
  • 50 Yang L, Tu L. Implications of gastrointestinal manifestations of COVID-19. Lancet Gastroenterol Hepatol 2020; 5 (07) 629-630 https://www.thelancet.com/journals/langas/article/PIIS2468-1253(20)30132-1/abstract [Internet]. Accessed Sep 29, 2020
  • 51 Pingel S. [Homeopathy. Basic aspects and principles of use in dermatology]. Hautarzt 1992; 43 (08) 475-482
  • 52 Liu W, Tao Z-W, Wang L. et al. Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease. Chin Med J (Engl) 2020; 133 (09) 1032-1038
  • 53 Sinha M, Roy E, Das S. et al. An observation on direct changes in Aedes albopictus midgut cells by Rhustox 6C in relation to dengue virus infection. Indian J Res Homoeopathy 2016; 10: 258-265
  • 54 Das S, Sinha M, Roy E. et al. Increased NS1 antigen expression by dengue virus infected vero cells under influence of ultra-diluted timber rattlesnake venom (Crotalus 6C). World J Pharm Pharm Sci 2017; 1096-1106
  • 55 Bandyopadhyay B, Das S, Sengupta M. et al. Decreased intensity of Japanese encephalitis virus infection in chick chorioallantoic membrane under influence of ultra-diluted Belladonna extract. Am J Infect Dis 2010; 6: 24-28
  • 56 Chakraborty U, Katoch S, Sinha M. et al. Changes in viral load in different organs of Japanese Encephalitis virus-infected chick embryo under the influence of Belladonna 200C. Indian J Res Homoeopathy 2018; 12: 75-80
  • 57 Chakraborty U, Sinha M, Bhattacharjee A. et al. Suppression of viral load by belladonna 200c through modulation of TLR and type-IIFN signalling pathways. Int J Biol Med Res 2019; 10 (01) 6635-6640
  • 58 Oberbaum M, Glatthaar-Saalmüller B, Stolt P, Weiser M. Antiviral activity of Engystol: an in vitro analysis. J Altern Complement Med 2005; 11 (05) 855-862
  • 59 Glatthaar-Saalmüller B. In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses. Can J Physiol Pharmacol 2007; 85 (11) 1084-1090
  • 60 Gupta P, Sundaram EN, Sharma M. et al. Pre-clinical pharmacology: An important aspect in homoeopathic research. Indian J Res Homoeopathy 2018; 12: 164-179
  • 61 Narayanan K, Ramirez SI, Lokugamage KG, Makino S. Coronavirus nonstructural protein 1: common and distinct functions in the regulation of host and viral gene expression. Virus Res 2015; 202: 89-100
  • 62 Wathelet MG, Orr M, Frieman MB, Baric RS. Severe acute respiratory syndrome coronavirus evades antiviral signaling: role of nsp1 and rational design of an attenuated strain. J Virol 2007; 81 (21) 11620-11633
  • 63 Cornillez-Ty CT, Liao L, Yates III JR, Kuhn P, Buchmeier MJ. Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling. J Virol 2009; 83 (19) 10314-10318
  • 64 Lei J, Kusov Y, Hilgenfeld R. Nsp3 of coronaviruses: structures and functions of a large multi-domain protein. Antiviral Res 2018; 149: 58-74
  • 65 Clementz MA, Kanjanahaluethai A, O'Brien TE, Baker SC. Mutation in murine coronavirus replication protein nsp4 alters assembly of double membrane vesicles. Virology 2008; 375 (01) 118-129
  • 66 Stobart CC, Sexton NR, Munjal H. et al. Chimeric exchange of coronavirus nsp5 proteases (3CLpro) identifies common and divergent regulatory determinants of protease activity. J Virol 2013; 87 (23) 12611-12618
  • 67 Zhu X, Fang L, Wang D. et al. Porcine deltacoronavirus nsp5 inhibits interferon-β production through the cleavage of NEMO. Virology 2017; 502: 33-38
  • 68 Cottam EM, Whelband MC, Wileman T. Coronavirus NSP6 restricts autophagosome expansion. Autophagy 2014; 10 (08) 1426-1441
  • 69 te Velthuis AJ, van den Worm SH, Snijder EJ. The SARS-coronavirus nsp7+nsp8 complex is a unique multimeric RNA polymerase capable of both de novo initiation and primer extension. Nucleic Acids Res 2012; 40 (04) 1737-1747
  • 70 Egloff M-P, Ferron F, Campanacci V. et al. The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world. Proc Natl Acad Sci U S A 2004; 101 (11) 3792-3796
  • 71 Wang Y, Sun Y, Wu A. et al. Coronavirus nsp10/nsp16 methyltransferase can be targeted by nsp10-derived peptide in vitro and in vivo to reduce replication and pathogenesis. J Virol 2015; 89 (16) 8416-8427
  • 72 Snijder EJ, Decroly E, Ziebuhr J. The nonstructural proteins directing coronavirus RNA synthesis and processing. Adv Virus Res 2016; 96: 59-126
  • 73 Becares M, Pascual-Iglesias A, Nogales A, Sola I, Enjuanes L, Zuñiga S. Mutagenesis of coronavirus nsp14 reveals its potential role in modulation of the innate immune response. J Virol 2016; 90 (11) 5399-5414
  • 74 Deng X, Hackbart M, Mettelman RC. et al. CoV nsp15 mediates evasion of dsRNA sensors. Proc Natl Acad Sci U S A 2017; 114 (21) 4251-4260
  • 75 Huh YH, Kim MJ, Yeo MG. Homeopathic Rhus toxicodendron treatment increased the expression of cyclooxygenase-2 in primary cultured mouse chondrocytes. Homeopathy 2013; 102 (04) 248-253
  • 76 Chirumbolo S, Signorini A, Bianchi I, Lippi G, Bellavite P. Effects of homeopathic preparations of organic acids and of minerals on the oxidative metabolism of human neutrophils. Br Hom J 1993; 82: 227-244
  • 77 Shah R. HIV nosode: the homeopathic pathogenetic trial. Forsch Komplement Med 2015; 22 (03) 156-162