Analysis of Basal Cell Carcinoma and Squamous Cell Carcinoma according to Nasal Subunit Location

Abstract

The nose is highly vulnerable to skin cancers due to the unavoidable sun exposure. The most common localization of skin cancers on the face is nose. Although the nose appears to be a single structure, it comprises many aesthetic units with different histological and anatomical properties. Our aim was to determine the relationship between the prevalence of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), histologically and anatomically distinct nasal subunits. The study included patients who underwent excision and repair due to BCC or SCC of the nose. The lesions were classified according to their location in the following topographic subunits: tip, alar lobule, dorsum, sidewall, and medial canthal region. Patients were analyzed according to age, sex, topographic subunit, tumor type, and repair technique. There was no statistically significant difference in tumor location according to etiology (p > 0.05). The alar subunit was the most common location of BCC, while the dorsum was the most common location for SCC. There is no statistical relationship between the two most common skin cancers, BCC and SCC, and the aesthetic subunits of the nose. The only factor associated with the reconstruction method used was the subunit in which the tumor was located.

Keywords

basal cell carcinoma - squamous cell carcinoma - nasal subunits - tip

Ethical Approval

Approval was obtained from Cumhuriyet University Ethics Committee (decision no: 2020–06/35, date: June,17, 2020).

Publication History

Article published online:
14 April 2021

• References

• 1 Evans GR, Williams JZ, Ainslie NB. Cutaneous nasal malignancies: is primary reconstruction safe?. Head Neck 1997; 19 (03) 182-187
• 2 Derebaşınlıoğlu H, Özkaya KN, Parlak BA. Evaluation of the cases who were referred to plastic surgery clinic out of suspicion of non-melanoma skin cancer localized at head and neck region in Sivas Numune Hospital. Turkiye Klinikleri J Dermatol 2016; 26 (02) 81-89
• 3 Mureau MAM, Moolenburgh SE, Levendag PC, Hofer SOP. Aesthetic and functional outcome following nasal reconstruction. Plast Reconstr Surg 2007; 120 (05) 1217-1227
• 4 Burget GC, Menick FJ. The subunit principle in nasal reconstruction. Plast Reconstr Surg 1985; 76 (02) 239-247
• 5 Gonzalez-Ulloa M, Castillo A, Stevens E, Alvarez Fuertes G, Leonelli F, Ubaldo F. Preliminary study of the total restoration of the facial skin. Plast Reconstr Surg (1946) 1954; 13 (03) 151-161
• 6 Rohrich RJ, Griffin JR, Ansari M, Beran SJ, Potter JK. Nasal reconstruction--beyond aesthetic subunits: a 15-year review of 1334 cases. Plast Reconstr Surg 2004; 114 (06) 1405-1416
• 7 Yotsuyanagi T, Yamashita K, Urushidate S, Yokoi K, Sawada Y. Nasal reconstruction based on aesthetic subunits in Orientals. Plast Reconstr Surg 2000; 106 (01) 36-44
• 8 Wollina U. Epithelial tumors of the outer nose. Indian J Dermatol 2003; 48: 194-199
• 9 Wollina U, Bennewitz A, Langner D. Basal cell carcinoma of the outer nose: overview on surgical techniques and analysis of 312 patients. J Cutan Aesthet Surg 2014; 7 (03) 143-150
• 10 Kurt Ozkaya N, Yeldir N, Yilmaz S. Role of intraoperative clean surgical margin determined with lesion size and duration to obtain appropriate histological clean surgical margin in high-risk basal cell carcinoma patients, according to National Comprehensive Cancer Network Criteria. J Craniofac Surg 2019; 30 (08) e748-e752
• 11 National Comprehensive Cancer Network. Clinical Practice Guidelines in Oncology, Basal Cell Skin Cancer: Version 1. 2018
• 12 National Comprehensive Cancer Network. Clinical Practice Guidelines in Oncology, Squamous Cell Skin Cancer: Version 1. 2018
• 13 Wettstein R, Erba P, Farhadi J. et al. Incomplete excision of basal cell carcinoma in the subunits of the nose. Scand J Plast Reconstr Surg Hand Surg 2008; 42 (02) 92-95
• 14 Beer GM, Bermoser K, Kompatscher P. Closure of nasal defects after tumor excision with local flaps. Aesthetic Plast Surg 1998; 22 (01) 42-47
• 15 Heckmann M, Zogelmeier F, Konz B. Frequency of facial basal cell carcinoma does not correlate with site-specific UV exposure. Arch Dermatol 2002; 138 (11) 1494-1497
• 16 Kiyohara T, Nakamaru S, Nagano N. et al. Two cases of infundibular squamous cell carcinoma on the nose with aggressive clinical behavior: case report and review of the published work. J Dermatol 2018; 45 (02) 220-223
• 17 Terashi H, Kurata S, Hashimoto H. et al. Adequate depth of excision for basal cell carcinoma of the nose. Ann Plast Surg 2002; 48 (02) 214-216
• 18 Robinson JK, Pollack SV, Robins P. Invasion of cartilage by basal cell carcinoma. J Am Acad Dermatol 1980; 2 (06) 499-505