Recurrent Central Serous Chorioretinopathy Under Combined Vemurafenib and Cobimetinib Treatment

Introduction

Mitogen-activated protein kinase (MAPK) inhibitor associated retinopathy (MAPK-retinopathy) resembling central serous chorioretinopathy (CSR) was described in few observational cohort-based studies [1], [2], [3] as well as in a case report [4]. Interestingly, the incidence of this complication seems to increase considerably under a combination of vemurafenib and cobimetinib as compared to vemurafenib monotherapy as was recently reported [2]. In this case symptoms of CSR started 3 days after introduction of vemurafenib and cobimetinib chemotherapy.

• References

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