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Klin Monbl Augenheilkd 2016; 233(04): 438-440
DOI: 10.1055/s-0041-111803
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Georg Thieme Verlag KG Stuttgart · New York

Peripheral Bilateral Telangiectasiae in Multiple Sclerosis Patients Treated with Interferon B1a

Beidseitige periphere Teleangiektasien bei Interferon-B1a-behandelten Multiple-Sklerose-Patienten
S. de Massougnes
1   Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland
2   Jules Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland
,
F.-X. Borruat
1   Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland
2   Jules Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland
,
A. Ambresin
1   Department of Ophthalmology, University of Lausanne, Lausanne, Switzerland
2   Jules Gonin Eye Hospital, Fondation Asile des Aveugles, Lausanne, Switzerland
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Publication History

Publication Date:
26 April 2016 (online)

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Introduction

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by myelin and oligodendrocytes damage, local gliosis and axonal injury. Ophthalmic manifestations include lesions of either the neuro-ophtalmic afferent visual pathway, the efferent oculomotor pathways, or the eye with anterior, intermediate or posterior uveitis [1]. The most common mode of presentation of MS is a relapsing remitting course [2], commonly treated with immunomodulatory agents, such as subcutaneous interferon beta1a injection (IB1a). The systemic use of IB1a can rarely be complicated by ischemic retinopathy accompanied by retinal hemorrhages, cotton wool spots and microvascular retinal occlusions affecting mostly the posterior pole [3], [4], [5]. All the above publications reported the disappearance of the retinal manifestations with the discontinuation of IB1a therapy. Clinical presentation of IB1a retinopathy is compared to the ischemic retinopathy associated with interferon alpha [6] and both molecules are structurally related and share a common ancestor [7]. We describe the ophthalmic features of two patients diagnosed with quiescent relapsing-remitting MS previously treated with IB1a who both exhibited asymptomatic bilateral peripheral retinal telangiectasiae.

 

  • References

  • 1 Zein G, Berta A, Foster CS. Multiple sclerosis-associated uveitis. Ocul Immunol Inflamm 2004; 12: 137-142
    CrossrefPubMedGoogle Scholar
  • 2 Katz Sand I. Classification, diagnosis and differential diagnosis of multiple sclerosis. Curr Opin Neurol 2015; 28: 193-205
    CrossrefPubMedGoogle Scholar
  • 3 Longmuir R, Lee AG, Rouleau J. Cotton wool spots associated with interferon beta-1 alpha therapy. Semin Ophthalmol 2007; 22: 49-53
    CrossrefPubMedGoogle Scholar
  • 4 Saito H, Suzuki M, Asakawa T et al. Retinopathy in a multiple sclerosis patient undergoing interferon-therapy. Mult Scler 2007; 13: 939-940
    CrossrefPubMedGoogle Scholar
  • 5 Bakri SJ, Swanson JW. Asymptomatic Peripheral Retinal Hemorrhages as a Manifestation of Interferon Beta 1a Retinopathy. Semin Ophthalmol 2015; 30: 56-57
    CrossrefPubMedGoogle Scholar
  • 6 Guyer DR, Tiedeman J, Yannuzzi LA et al. Interferon-associated retinopathy. Arch Ophthalmol 1993; 111: 350-356
    CrossrefPubMedGoogle Scholar
  • 7 Taniguchi T, Mantei N, Schwarzstein M. Human leukocyte and fibroblast interferons are structurally related. Nature 1980; 285: 547-549
    CrossrefPubMedGoogle Scholar
  • 8 Querques G, Bux AV. Leber miliary aneurysms and multiple sclerosis. Eur J Ophthalmol 2009; 19: 690-693
    PubMedGoogle Scholar
  • 9 Ortiz-Perez S, Martinez-Lapiscina EH, Gabilondo I et al. Retinal periphlebitis is associated with multiple sclerosis severity. Neurology 2013; 81: 877-881
    CrossrefPubMedGoogle Scholar
  • 10 Kerrison JB, Flynn T, Green WR. Retinal pathologic changes in multiple sclerosis. Retina 1994; 14: 445-451
    CrossrefPubMedGoogle Scholar