Researcher's Perspective on Upper Respiratory Tract Infections, Immunomodulatory and Antiviral Effects of High-Dilution Medicines

Abstract

Homoeopathic system of medicine is based on Law of Similars, that is, principle of ‘Like cures like’. These ultra-diluted forms of medicine are prescribed on the basis of symptom similarity (individualised therapeutic) which helps in stimulating body's own defence mechanisms to fight against the pathogen. Homoeopathy had been tested in various preclinical studies for deciphering its properties of immunomodulatory on markers like tumour necrosis factor alpha, CD4 and antiviral effects in adenovirus 5, herpes simplex virus-1, respiratory syncytial virus and human rhinovirus which are elaborated. Effects of homoeopathic medicine on mild viral infections and CD4+ count are elaborated. A note on study design based on clinical trial of upper respiratory tract infections might be helpful in designing study for exploring immunomodulatory and antiviral effects of homoeopathic medicines.

Keywords

antiviral - homoeopathic - immunomodulatory

Publication History

Article published online:
20 October 2023

• References

• 1 Poitevin B, Davenas E, Benveniste J. In vitro immunological degranulation of human basophils is modulated by lung histamine and Apis mellifica. Br J Clin Pharmacol 1988; 25 (04) 439-444
• 2 Sainte-Laudy J, Sambucy JL, Belon P. Biological activity of ultra low doses I. Effect of ultra low doses of histamine on human basophil degranulation triggered by D. pteronissinus extract. In: Doutremepuich C. ed. Ultra Low Doses. London: Taylor and Francis; 1991: 127-138
• 3 Davenas E, Beauvais F, Amara J. et al. Human basophil degranulation triggered by very dilute antiserum against IgE. Nature 1988; 333 (6176): 816-818
• 4 Patil AD, Wakte M, Patel M, Gowda S. A review on preclinical studies conducted with homeopathic medicine Cephalandra indica as an anti-hyperglycemic agent. Int J High Dilution Res 2020; 18 (3–4): 35-46
• 5 Patil AD, Kathade SA, Aswani MA. et al. An in vitro antifungal activity of various potencies of homeopathic medicines against Fusarium moniliforme plant fungus. In J Res 2018; 7 (XI): 796-802
• 6 Patil AD, Chinche AD, Singh AK. et al. Ultra high dilutions: a review on in vitro studies against pathogens. Afr J Biotechnol 2019; 18 (13) 275-279
• 7 Gupta VK, Mathur M. Immunomodulatory effects of homoeopathic medicines: a review of pre-clinical studies. Indian J Res Homoeopathy 2018; 12: 90-94
• 8 Gupta P, Sundaram EN, Sharma M. et al. Pre-clinical pharmacology: an important aspect in homoeopathic research. Indian J Res Homoeopathy 2018; 12: 164-179
• 9 Oberbaum M, Glatthaar-Saalmüller B, Stolt P, Weiser M. Antiviral activity of Engystol: an in vitro analysis. J Altern Complement Med 2005; 11 (05) 855-862
• 10 Mayer J, Williams RJ, Oppenheimer VA. et al. The immunomodulatory effects of a commercial antiviral homeopathic compound in C57BL/6 mice, pre and post vaccine challenge. Int Immunopharmacol 2016; 39: 389-396
• 11 Glatthaar-Saalmüller B. In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses. Can J Physiol Pharmacol 2007; 85 (11) 1084-1090
• 12 Bandyopadhyay B, Das S, Sengupta M. et al. Decreased intensity of Japanese encephalitis virus infection in chick chorioallantoic membrane under influence of ultradiluted Belladonna extract. Am J Infect Dis 2010; 6: 24-28
• 13 See DM, Tilles JG, Bertacchini C. Immunomodulatory effects of a homeopathic agent. Am J Nat Med 1998; 5: 6
• 14 Beatriz Cesar, Ana Paula R.Abud, Carolina C.de Oliveira, Francolino Cardoso, Raffaello Popa Di Bernardi, Fernando S F.Guimaraes, Juarez Gabardo, Dorly de Freitas Buchi. Treatment with at Homeopathic Complex Medication Modulates Mononuclear Bone Marrow Cell Differentiation, Evidence-Based Complementary and Alternative Medicine, vol. . 2011, Article ID 212459, 10 pages, 2011
• 15 Ramchandani NM. Complementary therapies in clinical practice. 2010; 16: 101-108
• 16 Thinesse-Mallwitz M, Maydannik V, Keller T, Klement P. A homeopathic combination preparation in the treatment of feverish upper respiratory tract infections: an international randomized controlled trial. Forsch Komplement Med 2015; 22 (03) 163-170
• 17 Rabe A, Weiser M, Klein P. Effectiveness and tolerability of a homoeopathic remedy compared with conventional therapy for mild viral infections. Int J Clin Pract 2004; 58 (09) 827-832
• 18 Kuzeff RM. Homeopathy, sensation of well-being and CD4 levels: a placebo-controlled, randomized trial. Complement Ther Med 1998; 6: 4-9