Wang Z,
Wang X,
Wang P,
Zhao J.
*
Guangzhou Medical University, Northwestern Polytechnical University, Xi’an, Jiangxi
Normal University, Nanchang, and Nankai University, Tianjin, P. R. of China
Allenone-Mediated Racemization/Epimerization-Free Peptide Bond Formation and Its Application
in Peptide Synthesis.
J. Am. Chem. Soc. 2021;
143: 10374-10381
DOI:
10.1021/jacs.1c04614
Key words
allenones - α-carbonyl vinyl esters - peptide-bond formation
Significance
The development of an efficient method for amide bond formation is important in peptide
drug discovery. The authors have developed an allenone-mediated peptide synthesis.
Comment
This allenone-mediated amidation reaction affords peptides containing a variety of
amino acid residues in high yields without any epimerization.
