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Synfacts 2021; 17(09): 0959
DOI: 10.1055/s-0040-1720836
DOI: 10.1055/s-0040-1720836
Synthesis of Natural Products and Potential Drugs
Total Synthesis of (+)-Fortalpinoid A and (+)-Cephinoid H
Ren Z,
Sun Z,
Li Y,
Fan X,
Dai M,
Wang Y,
Hu X.
*
Northwest University, Xi'an, P. R. of China
Total Synthesis of (+)-3-Deoxyfortalpinoid F, (+)-Fortalpinoid A, and (+)-Cephinoid H.
Angew. Chem. Int. Ed. 2021;
60: 18572-18576
DOI: 10.1002/anie.202108034.
Total Synthesis of (+)-3-Deoxyfortalpinoid F, (+)-Fortalpinoid A, and (+)-Cephinoid H.
Angew. Chem. Int. Ed. 2021;
60: 18572-18576
DOI: 10.1002/anie.202108034.
Key words
cephalotaxus - (+)-fortalpinoid A - (+)-cephinoid H - Pauson–Khand cyclization - ring-closing metathesis
Significance
Hu and co-workers report the first total synthesis of (+)-fortalpinoid A and (+)-cephanoid A, members of a class of 17,17-norditerpenoids, isolated from Cephalotaxus fortunii.
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Comment
Allyl alcohol B is accessed from vinylogous ester A, first described by Myers and co-workers, and elaborated into enyne D, which then undergoes the key carbonylative cyclization to furnish E and give access to three natural products.
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Publication History
Article published online:
18 August 2021
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