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Synfacts 2021; 17(08): 0953
DOI: 10.1055/s-0040-1720345
Flow Chemistry

Single-Flow System for Acid Hydrolysis and Base Condensation

Contributor(s):
Yasuhiro Uozumi
,
Ryoko Niimi
Borah P, Fianchini M, Pericàs MA. * The Barcelona Institute of Science and Technology, ICIQ, Tarragona, Spain
Assessing the Role of Site Isolation and Compartmentalization in Packed-Bed Flow Reactors for Processes Involving Wolf-and-Lamb Scenarios.

ACS Catal. 2021;
11: 6234-6242
DOI: 10.1021/acscatal.1c00889.
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Key words

acid hydrolysis - Henry reaction - Knoevenagel reaction - mesoporous silica

Significance

Two types of SBA-15-based mesoporous silica bearing sulfonic acid groups (SBA-SO3H) and amine groups (SBA-NH2), respectively, were prepared according to equation 1. Acid hydrolysis of acetals and subsequent C–C bond-forming condensation (i.e., a Henry reaction and a ­Knoevenagel reaction) were achieved in a flow ­system using a single packed-bed reactor charged with SBA-SO3H and SBA-NH2 (eq. 2).


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Comment

SBA-SO3H and SBA-NH2 were characterized by TEM, FT-IR, N2 adsorption and desorption, BET, TGA, and TPD analyses. The authors also prepared a catalyst functionalized with both SO3H and NH2 groups, SBA- SO3H/NH2, but its catalytic activity was inferior to that of a physical mixture of SBA-SO3H and SBA-NH2.


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Publication History

Article published online:
20 July 2021

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