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Synthesis of HIV Integrase Inhibitor MK-1376
Synthesis of Fused Oxepane HIV integrase Inhibitor MK-1376.
Key wordsMK-1376 - HIV integrase inhibitor - π-allyl alkylation - palladium catalysis - quinone methide
MK-1376 is an HIV integrase inhibitor that is of interest for the treatment of AIDS. The key step in the synthesis of MK-1376 is the Trost palladium-catalyzed asymmetric π-allylation reaction that installed the stereogenic center at C-6 in the 1,4-oxazepane ring of C. Prolonged reaction times led to erosion of ee from reversible ring closure. This is the first example of reversibility in a π-allylation reaction. The epimerization processes were suppressed by addition of 1.5 mol% palladium acetate prior to workup.
Introduction of the stereogenic center at C-10 was accomplished by reaction of methylamine with the amides Ha,b (syn/anti = 1:1) that gave the syn-isomer J (syn/anti = 97:3), independent of the original stereochemistry at C-10, consistent with the diastereoselective addition of methylamine to quinone methide intermediate I.
16 December 2020 (online)
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