Volumetric Capnography in Pediatric Extracorporeal Membrane Oxygenation: A Case Series

Abstract

The kinetics of carbon dioxide elimination (VCO₂) may be used as a surrogate for pulmonary blood flow. As such, we can apply a novel use of volumetric capnography to assess hemodynamic stability in patients requiring extracorporeal membrane oxygenation (ECMO). We report our experience of pediatric patients requiring ECMO support who were monitored using volumetric capnography. We describe the use of VCO₂ and its association with successful decannulation. This is a prospective observational study of pediatric patients requiring ECMO support at The Children's Hospital at Montefiore from 2017 to 2019. A Respironics NM3 monitor was applied to each patient. Demographics, hemodynamic data, blood gases, and VCO₂ (mL/min) data were collected. Data were collected immediately prior to and after decannulation. Over the course of the study period, seven patients were included. Predecannulation VCO₂ was higher among patients who were successfully decannulated than nonsurvivors (109 [35, 230] vs. 12.4 [7.6, 17.2] mL/min), though not statistically significant. Four patients (57%) survived without further mechanical support; two (29%) died, and one (14%) was decannulated to Berlin. Predecannulation VCO₂ appears to correlate with hemodynamic stability following decannulation. This case series adds to the growing literature describing the use of volumetric capnography in critical care medicine, particularly pediatric patients requiring ECMO. Prospective studies are needed to further elucidate the use of volumetric capnography and optimal timing for ECMO decannulation.

Keywords

ECMO - device - noninvasive

Authors' Contributions

Each author, K.R.D., S.S.M, S.I.A., S.K., A.A.-S, and G.O.-A., contributed substantially to the conception and design of this work, the acquisition, analysis, and interpretation of the data, as well as drafting and editing the manuscript. Each author approved the final version of the manuscript for publication.

Note

This study was presented at the Society of Critical Care Medicine Annual Congress 2019 in San Diego, California, United States, and the abstract was published in Critical Care Medicine in January 2019.

Publication History

Received: 30 July 2020

Accepted: 30 August 2020

Article published online:
05 October 2020

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