J Pediatr Intensive Care 2021; 10(03): 188-196
DOI: 10.1055/s-0040-1715850
Original Article

Does Non-Neurologic Multiorgan Dysfunction After Out-of-Hospital Cardiac Arrest among Children Admitted in Coma Predict Outcome 1 Year Later?

Kelly L. Corbett
1   Department of Pediatrics, Section of Critical Care Medicine, Dartmouth-Hitchcock Medical Center, Lebanon
,
Angela P. Presson
2   Department of Pediatrics, Division of Critical Care Medicine, University of Utah, Salt Lake City, Utah, United States
3   Department of Internal Medicine, Division of Epidemiology, University of Utah, Salt Lake City, Utah, United States
,
Chong Zhang
3   Department of Internal Medicine, Division of Epidemiology, University of Utah, Salt Lake City, Utah, United States
,
Yizhe Xu
3   Department of Internal Medicine, Division of Epidemiology, University of Utah, Salt Lake City, Utah, United States
,
Susan L. Bratton
2   Department of Pediatrics, Division of Critical Care Medicine, University of Utah, Salt Lake City, Utah, United States
,
Rebecca R. Dixon
4   Department of Pediatrics, Washington Permanente Medical Group, Spokane, Washington, United States
› Author Affiliations
Funding This investigation was supported by the University of Utah Population Health Research Foundation, with funding in part from the National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health, through Grant UL1TR002538 (formerly 5UL1TR001067–05, 8UL1TR000105, and UL1RR025764).

Abstract

In this article, we investigated whether non-neurologic multiorgan dysfunction syndrome (MODS) following out-of-hospital cardiac arrest (OHCA) predicts poor 12-month survival. We conducted a secondary data analysis of therapeutic hypothermia after pediatric cardiac arrest out-of-hospital randomized trial involving children who remained unconscious and intubated after OHCA (n = 237). Associations between MODS and 12-month outcomes were assessed using multivariable logistic regression. Non-neurologic MODS was present in 95% of patients and sensitive (97%; 95% confidence interval [CI]: 93–99%) for 12-month survival but had poor specificity (10%; 95% CI: 4–21%). Development of non-neurologic MODS is not helpful to predict long-term neurologic outcome or survival after OHCA.

Note

This work was performed at the University of Utah.


Supplementary Material



Publication History

Received: 22 April 2020

Accepted: 02 July 2020

Article published online:
11 September 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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