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J Knee Surg 2021; 34(13): 1463-1468
DOI: 10.1055/s-0040-1710364
Original Article

Magnesium Sulfate Combined with a Levobupivacaine Periarticular Cocktail for Analgesia in the Early Postoperative Period after Total Knee Arthroplasty

Zhenrui Zhao
1   Department of Orthopedics, Wuhan University of Science and Technology, Xiaogan, Hubei, China
2   Department of Orthopedics, North Sichuan Medical College, Nanchong, Sichuan, China
,
Xiaozhou Zhang
1   Department of Orthopedics, Wuhan University of Science and Technology, Xiaogan, Hubei, China
,
Hao Peng
3   Department of Orthopedics, Wuhan University, Wuhan, Hubei, China
,
Wei Li
2   Department of Orthopedics, North Sichuan Medical College, Nanchong, Sichuan, China
,
Hengzhong Liu
1   Department of Orthopedics, Wuhan University of Science and Technology, Xiaogan, Hubei, China
,
Hang Wu
1   Department of Orthopedics, Wuhan University of Science and Technology, Xiaogan, Hubei, China
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Abstract

This study aimed to evaluate the analgesic effect of magnesium sulfate combined with a levobupivacaine periarticular cocktail in the early postoperative period after total knee arthroplasty (TKA). A total of 60 patients who underwent primary unilateral TKA in our department from March 2018 to May 2019 were prospectively selected and randomly divided into the trial group (30 patients with 20 mL of magnesium sulfate 250 mg + levobupivacaine 50 mg + triamcinolone 25 mg + 0.9% normal saline) and the control group (30 patients with 20 mL of levobupivacaine 50 mg + triamcinolone 25 mg + 0.9% normal saline). Visual analog scale (VAS) scores at 6, 12, 24, 48, and 72 hours postoperatively during rest; VAS scores at 12, 24, 48, and 72 hours postoperatively during motion; the time required to reach 30 degrees straight leg elevation and 60 degrees active knee flexion; and the analgesia pump dosage at 6, 12, 24, and 48 hours postoperatively were recorded. Magnesium sulfate combined with levobupivacaine injection around the knee joint can significantly prolong the time of postoperative analgesia, significantly reduce the use of postoperative analgesics, and effectively alleviate early postoperative pain after TKA.

Keywords

total knee arthroplasty - analgesia - magnesium sulfate - levobupivacaine - periarticular cocktail injection


Publication History

Received: 25 July 2019

Accepted: 21 March 2020

Article published online:
20 May 2020

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