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Am J Perinatol 2021; 38(S 01): e239-e248
DOI: 10.1055/s-0040-1709464
Original Article

Maternal and Neonatal Outcomes Associated with Amniotomy among Nulliparous Women Undergoing Labor Induction at Term

Authors

  • Ashley N. Battarbee 

    1   Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina

  • Grecio Sandoval

    2   Department of Obstetrics and Gynecology, The George Washington University Biostatistics Center, Washington, District of Columbia

  • William A. Grobman

    3   Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois

  • Uma M. Reddy

    4   The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland

  • Alan T.N. Tita

    5   Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama

  • Robert M. Silver

    6   Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City, Utah

  • Yasser Y. El-Sayed

    7   Department of Obstetrics and Gynecology, Stanford University, Stanford, California

  • Ronald J. Wapner

    8   Department of Obstetrics and Gynecology, Columbia University, New York, New York

  • Dwight J. Rouse

    9   Department of Obstetrics and Gynecology, Brown University, Providence, Rhode Island

  • George R. Saade

    10   Department of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas

  • Suneet P. Chauhan

    11   Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston-Children's Memorial Hermann Hospital, Houston, Texas

  • Jay D. Iams

    12   Department of Obstetrics and Gynecology, The Ohio State University, Columbus, Ohio

  • Edward K. Chien

    13   Department of Obstetrics and Gynecology, MetroHealth Medical Center-Case Western Reserve University, Cleveland, Ohio

  • Brian M. Casey

    14   Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas

  • Ronald S. Gibbs

    15   Department of Obstetrics and Gynecology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado

  • Sindhu K. Srinivas

    16   Department of Obstetrics and Gynecology, University of Pennsylvania, Philadelphia, Pennsylvania

  • Geeta K. Swamy

    17   Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina

  • Hyagriv N. Simhan

    18   Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania
    • for the Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units (MFMU) Network

Funding The study was funded Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD40512, HD36801, HD27869, HD34208, HD68268, HD40485, HD40500, HD53097, HD40560, HD40545, HD27915, HD40544, HD34116, HD68282, HD87192, HD68258, HD87230) and the National Center for Advancing Translational Sciences (UL1TR001873). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
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Abstract

Objective The aim of the study is to evaluate the association between amniotomy at various time points during labor induction and maternal and neonatal outcomes among term, nulliparous women.

Study Design Secondary analysis of a randomized trial of term labor induction versus expectant management in low-risk, nulliparous women (2014–2017) was conducted. Women met inclusion criteria if they underwent induction ≥38 weeks' gestation using oxytocin with documented time and type of membrane rupture. Women with antepartum stillbirth or fetal anomaly were excluded. The primary outcome was cesarean delivery. Secondary outcomes included maternal and neonatal complications. Maternal and neonatal outcomes were compared among women with amniotomy versus women with intact membranes and no amniotomy at six 2-hour time intervals: before oxytocin initiation, 0 to <2 hours after oxytocin, 2 to <4 hours after, 4 to <6 hours after, 6 to <8 hours after, and 8 to <10 hours after. Multivariable logistic regression adjusted for maternal age, body mass index, race/ethnicity, modified Bishop score on admission, treatment group, and hospital (as a random effect).

Results Of 6,106 women in the parent trial, 2,854 (46.7%) women met inclusion criteria. Of these 2,340 (82.0%) underwent amniotomy, and majority of the women had amniotomy performed between 2 and <6 hours after oxytocin. Cesarean delivery was less frequent among women with amniotomy 6 to <8 hours after oxytocin compared with women without amniotomy (21.9 vs. 29.7%; adjusted odds ratio 0.61, 95% confidence interval 0.42–0.89). Amniotomy at time intervals ≥4 hours after oxytocin was associated with lower odds of labor duration >24 hours. Amniotomy at time intervals ≥2 hours and <8 hours after oxytocin was associated with lower odds of maternal hospitalization >3 days. Amniotomy was not associated with postpartum or neonatal complications.

Conclusion Among a contemporary cohort of nulliparous women undergoing term labor induction, amniotomy was associated with either lower or similar odds of cesarean delivery and other adverse outcomes, compared with no amniotomy.

Keywords

amniotomy - artificial rupture of membranes - cesarean - induction - labor - nulliparous

Note

This work has been presented in the oral plenary at the 39th annual meeting of the Society for Maternal–Fetal Medicine, Las Vegas, NV, February 11 to 16, 2019.


* A list of other members of the NICHD MFMU Network is available in the [Supplementary Material].


Supplementary Material



Publikationsverlauf

Eingereicht: 02. März 2020

Angenommen: 04. März 2020

Artikel online veröffentlicht:
16. April 2020

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