Synfacts 2020; 16(05): 0537
DOI: 10.1055/s-0040-1707549
Metals in Synthesis
© Georg Thieme Verlag Stuttgart · New York

Nickel-Catalyzed anti-Markovnikov Hydroarylation of Unactivated Alkenes

Contributor(s):
Mark Lautens
,
Randy Sanichar
Saper NI, Ohgi A, Small DW, Semba K, Nakao Y. * Hartwig JF. * University of California, Berkeley, USA; Kyoto University, Japan
Nickel-Catalysed anti-Markovnikov Hydroarylation of Unactivated Alkenes with Unactivated Arenes Facilitated by Non-Covalent Interactions.

Nat. Chem. 2020;
12: 276-283
Further Information

Publication History

Publication Date:
20 April 2020 (online)

 

Significance

Nakao, Hartwig and co-workers report a novel nickel-catalyzed undirected hydroarylation reaction between unactivated alkenes and unactivated arenes. The reaction proceeds in excellent yields with high selectivity for the anti-­Markovnikov product. These products are distinct from those accessed through acid-catalyzed processes.


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Comment

The authors characterized the catalytically relevant substrate bound nickel complexes and identified the reductive elimination step forming the C–C bond as the rate-limiting step. They also note that differences in the activity between catalysts with large/small carbenes are more dependent on the stabilizing intramolecular noncovalent interactions in the secondary coordination sphere, than steric hindrance.


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