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DOI: 10.1055/s-0040-1707549
Nickel-Catalyzed anti-Markovnikov Hydroarylation of Unactivated Alkenes
Publication History
Publication Date:
20 April 2020 (online)
Key words
nickel catalysis - C–H activation - hydroarylation - unactivated alkenes - anti-Markovnikov reaction
Significance
Nakao, Hartwig and co-workers report a novel nickel-catalyzed undirected hydroarylation reaction between unactivated alkenes and unactivated arenes. The reaction proceeds in excellent yields with high selectivity for the anti-Markovnikov product. These products are distinct from those accessed through acid-catalyzed processes.
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Comment
The authors characterized the catalytically relevant substrate bound nickel complexes and identified the reductive elimination step forming the C–C bond as the rate-limiting step. They also note that differences in the activity between catalysts with large/small carbenes are more dependent on the stabilizing intramolecular noncovalent interactions in the secondary coordination sphere, than steric hindrance.
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