Tantalum-or Titanium-Catalyzed Peptide Synthesis
Substrate-Directed Lewis-Acid Catalysis for Peptide Synthesis.
J. Am. Chem. Soc. 2019;
15 May 2020 (online)
The development of elegant synthetic methodologies for peptide-bond formation is a highly demanding task in organic synthesis. A substrate-directed, Lewis acid-catalyzed, racemization-free amidation method has been developed to access various peptides.
The tantalum-catalyzed substrate-directed peptide-bond-formation reaction proceeds with various amino acids under solvent-free conditions and delivers peptides in high yields without racemization. This method further extends titanium-catalyzed oligopeptide synthesis.