Synfacts 2020; 16(06): 0731
DOI: 10.1055/s-0040-1707543
Peptide Chemistry
© Georg Thieme Verlag Stuttgart · New York

Tantalum-or Titanium-Catalyzed Peptide Synthesis

Hisashi Yamamoto
Isai Ramakrishna
Muramatsu W. * Hattori T, Yamamoto H. * Chubu University, Kasugai, Japan
Substrate-Directed Lewis-Acid Catalysis for Peptide Synthesis.

J. Am. Chem. Soc. 2019;
141: 12288-12295
Further Information

Publication History

Publication Date:
15 May 2020 (online)



The development of elegant synthetic methodologies for peptide-bond formation is a highly demanding task in organic synthesis. A substrate-directed, Lewis acid-catalyzed, racemization-free amidation method has been developed to access various peptides.



The tantalum-catalyzed substrate-directed peptide-bond-formation reaction proceeds with various amino acids under solvent-free conditions and delivers peptides in high yields without racemization. This method further extends titanium-catalyzed oligopeptide synthesis.