RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2020; 16(06): 0661
DOI: 10.1055/s-0040-1706971
DOI: 10.1055/s-0040-1706971
Metals in Synthesis
Nickel-Catalyzed Cross-Electrophile Coupling using Electrochemistry
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
15. Mai 2020 (online)

Significance
The authors describe a general nickel-catalyzed cross-electrophile coupling of functionalized alkenyl, aryl, and heteroaryl halides with various primary and secondary bromides using electrochemistry. The alkylated products were obtained in high yields.
#
Comment
Key for high coupling yields was the use of the electron shuttle reagent Ni(η3-L)2, which efficiently prevents over-reduction and thus decomposition of the unsaturated halides. Significantly, this enables an easy scale up by performing the reaction at high currents on a 75 mmol scale.
#
#
