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Synfacts 2020; 16(12): 1495
DOI: 10.1055/s-0040-1706596
DOI: 10.1055/s-0040-1706596
Peptide Chemistry
Synthesis of Reactive Amino Acid Esters by Using Amino Acid Chlorides in a Biphasic System
Suresh Babu VV,
*,
Ananda K,
Mathad RI.
Bangalore University, India
Synthesis of Pentafluorophenyl, 2,4,5-Trichlorophenyl and Pentachlorophenyl Esters of Fmoc-Amino Acids Using Fmoc-Amino Acid Chlorides as Intermediates.
Lett. Pept. Sci. 2000;
7: 239-242
DOI: 10.1023/a:1011218219999.
Synthesis of Pentafluorophenyl, 2,4,5-Trichlorophenyl and Pentachlorophenyl Esters of Fmoc-Amino Acids Using Fmoc-Amino Acid Chlorides as Intermediates.
Lett. Pept. Sci. 2000;
7: 239-242
DOI: 10.1023/a:1011218219999.
Significance
Reactive amino acid phenyl esters have been used in peptide synthesis. The authors developed a method where amino acid chlorides and inorganic base are used to prepare reactive amino acid esters in a two-phase system.
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Comment
With the inorganic base NaHCO3, various reactive amino acid phenyl esters can be synthesized without using classical peptide-coupling reagents. The yields of the reactions were moderate to good.
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Publication History
Article published online:
17 November 2020
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