Suresh Babu VV,
*,
Ananda K,
Mathad RI.
Bangalore University, India
Synthesis of Pentafluorophenyl, 2,4,5-Trichlorophenyl and Pentachlorophenyl Esters
of Fmoc-Amino Acids Using Fmoc-Amino Acid Chlorides as Intermediates.
Lett. Pept. Sci. 2000;
7: 239-242
DOI:
10.1023/a:1011218219999
Key words
amino acid chlorides - phenols - amino acid esters - biphasic system
Significance
Reactive amino acid phenyl esters have been used in peptide synthesis. The authors
developed a method where amino acid chlorides and inorganic base are used to prepare
reactive amino acid esters in a two-phase system.
Comment
With the inorganic base NaHCO3, various reactive amino acid phenyl esters can be synthesized without using classical
peptide-coupling reagents. The yields of the reactions were moderate to good.
