Synfacts 2021; 17(07): 0803
DOI: 10.1055/s-0040-1706257
Organo- and Biocatalysis

Heterofunctionalization of Arenes by Electrophotocatalysis

Benjamin List
Luc M. Debie
Huang H, Lambert TH. * Cornell University, Ithaca, USA
Electrophotocatalytic C−H Heterofunctionalization of Arenes.

Angew. Chem. Int. Ed. 2021;
60: 11163-11167
DOI: 10.1002/anie.202100222.


Huang and Lambert report an oxidant-free electrophotocatalytic heterofunctionalization of arenes, in which electron-deficient or electron-neutral arenes are readily functionalized with various oxygen and nitrogen nucleophiles. The reaction is shown to be compatible with a wide range of arenes, and moderate to good yields and regioselectivity are achieved.



The authors’ reaction improves upon a previously reported arene heterofunctionalization using catalytic DDQ (see: P. Natarajan, B. König Eur. J. Org. Chem. 2021, 2145) by combining the photocatalytic and electrolytic processes to facilitate a lower catalyst loading, as well as eliminating the need for an additional oxidant, such as the potentially explosive mixture of tert-butyl nitrite and air.


Publication History

Article published online:
17 June 2021

© 2021. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany