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Heterofunctionalization of Arenes by Electrophotocatalysis
Electrophotocatalytic C−H Heterofunctionalization of Arenes.
Angew. Chem. Int. Ed. 2021;
Huang and Lambert report an oxidant-free electrophotocatalytic heterofunctionalization of arenes, in which electron-deficient or electron-neutral arenes are readily functionalized with various oxygen and nitrogen nucleophiles. The reaction is shown to be compatible with a wide range of arenes, and moderate to good yields and regioselectivity are achieved.
The authors’ reaction improves upon a previously reported arene heterofunctionalization using catalytic DDQ (see: P. Natarajan, B. König Eur. J. Org. Chem. 2021, 2145) by combining the photocatalytic and electrolytic processes to facilitate a lower catalyst loading, as well as eliminating the need for an additional oxidant, such as the potentially explosive mixture of tert-butyl nitrite and air.
Article published online:
17 June 2021
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