Subscribe to RSS
Anhydride-Mediated Peptide Synthesis with C-Terminal Unprotected N-Methylamino Acids
Isostearyl Mixed Anhydrides for the Preparation of N‑Methylated Peptides Using C‑Terminally Unprotected N‑Methylamino Acids.
Org. Lett. 2020;
The synthesis of N-methylated peptides is an important field in organic chemistry and medicinal chemistry. The authors used isostearic acid bromide to generate mixed anhydrides to react with C-terminal-unprotected N-methylamino acids to prepare N-methylated peptides with the assistance of a silylation reagent.
Various N-methylated peptides were prepared through the mixed anhydrides intermediate. The reaction proceeds under mild conditions, and the yields of the desired products are good to excellent.
16 December 2020 (online)
© 2020. Thieme. All rights reserved
Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany