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Peptide Bond Formation by Using p-Nitrophenyl Esters
Peptide Coupling of Unprotected Amino Acids through in situ p-Nitrophenyl Ester Formation.
Tetrahedron Lett. 2002;
Reactive amino acid phenyl esters have been used in peptide synthesis. In 2002, Keillor and co-workers reported a method for peptide bond formation between p-nitrophenyl esters and unprotected amino acids in aqueous solution.
By using p-nitrophenyl esters formed in situ, various dipeptides or tripeptides were synthesized without classical peptide-coupling reagents. The yields of the target peptides were moderate to excellent.
16 December 2020 (online)
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