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Synfacts 2020; 16(09): 1115
DOI: 10.1055/s-0040-1705854
DOI: 10.1055/s-0040-1705854
Peptide Chemistry
An N-Protecting Group for Solid-Phase Peptide Synthesis in Aqueous Media
Key words
solid-phase synthesis - peptide synthesis - aqueous media - protecting group - fluorescenceSignificance
Peptide synthesis in water as the solvent is underdeveloped. The author have developed a solid-phase peptide synthesis (SPPS) in aqueous media by using a new 2,7-disulfo-9-fluorenylmethoxycarbonyl (Smoc) N-protecting group.
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Comment
The authors developed the Smoc group as an N-protecting group. The Smoc group, which is fluorescent, can be used for SPPS in aqueous media and is easily removed.
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Publication History
Article published online:
18 August 2020
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