Gegen Schmerz und Krebs – Ein Plädoyer für Integrative Medizin

Abstract

Dieser Beitrag zeigt am Beispiel der Schmerztherapie bzw. der begleitenden Behandlung von Patienten mit onkologischen Erkrankungen, der sog. Integrativen Onkologie, die wissenschaftlich geprägten Anwendungsmöglichkeiten der Naturheilkunde und Integrativen Medizin. Es geht dabei nicht um ein Entweder-oder, sondern um die Entwicklung gemeinsamer Therapiekonzepte zum Wohle der Patienten. Es bleibt zu hoffen, dass künftig nicht mehr traditionelle Glaubenssätzen sowie die oftmals tiefe Spaltung zwischen Schulmedizin und Naturheilkunde das Miteinander bestimmen, sondern Wissenschaft, ärztliche Erfahrung und ein sinnvolles Ergänzen bzw. ein Voneinander-Lernen.

Schlüsselwörter:

Integrative Medizin - Naturheilkunde - Komplementärmedizin - Mind-Body-Medizin - Schmerztherapie - Integrative Onkologie

• Literatur

• 1 WHO. Highlights on health in Germany 2004. Im Internet: http://www.euro.who.int/en/countries/germany/publications3/highlights-on-health-in-germany-2004 Stand 01.07.2015
• 2 Eisenberg DM, Kessler RC, Foster C et al. Unconventional medicine in the United States. Prevalence, costs, and patterns of use. NEJM 1993; 328: 246-252
• 3 Bucker B, Groenewold M, Schoefer Y et al. The use of complementary alternative medicine (CAM) in 1001 German adults: results of a populationbased telephone survey. Gesundheitswesen 2008; 70: 29-36
• 4 Rampp T, Cramer H, Dobos G. Komplementäre Verfahren in der Schmerztherapie. In: Diener CH, Maier C, Bingel U., Hrsg. Das Schmerztherapie Buch: medikamentös – interventionell – psychologisch. 5. Aufl. München: Urban und Fischer Verlag/Elsevier GmbH; 2015
• 5 Sagar SM, Leis AM. Integrative oncology: a Canadian and international perspective. CurrCncol 2008; 15 (Suppl. 01) 71-73
• 6 Cramer H, Cohen L, Dobos G et al. Integrative oncology: best of both worlds – theoretical, practical, and research issues. Evid Based Complement Alternat Med 2013; 2013: 383142-383142
• 7 Barrie R, Cassileth GE, Deng JE et al. Complementary therapies and integrative oncology in lung cancer: ACCP evidence-based Clinical Practice Guidelines (2nd Edition). Chest 2007; 132
• 8 Deng GE, Cassileth BR, Cohen L et al. Integrative Oncology Practice Guidelines. J SocIntegrOncol 2007; 5: 65-84
• 9 Fair WR., Willet Jr. F.Whitore. Lecture: back to the future – the role of complementary medicine in urology. J Urol 1999; 162: 411-420
• 10 Deng GE, Frenkel M, Cohen L et al. Evidence-based clinical practice guidelines for integrative oncology: complementary therapies and botanicals. J SocIntegrOncol 2009; 7: 85-120
• 11 Greenlee H, Balneaves LG, Carlson LE et al. Clinical practice guidelines on the use of integrative therapies as supportive care in patients treated for breast cancer. J Natl Cancer InstMonogr 2014; 2014: 346-358
• 12 Blaes AH, Kreitzer MJ, Torkelson C et al. Nonpharmacologic complementary therapies in symptom management for breast cancer survivors. Seminoncol 2011; 38: 394-402
• 13 Casla S, Hojman P, Marquez-Rodas I et al. Running away from side effects: physical exercise as a complementary intervention for breast cancer patients. ClinTranslOncol 2015; 17: 180-196
• 14 Finnegan-John J, Molassiotis A, Richardson A et al. A systematic review of complementary and alternative medicine interventions for the management of cancer-related fatigue. Integr Cancer Ther 2013; 12: 276-290
• 15 Fasching PA, Thiel F, Nicolaisen-Murmann K et al. Association of complementary methods with quality of life and life satisfaction in patients with gynecologic and breast malignancies. Support Care Cancer 2007; 15: 1277-1284
• 16 Molassiotis A, Browall M, Milovics L et al. Complementary and alternative medicine use in patients with gynecological cancers in Europe. Int J Gynecol Cancer 2006; 16 (Suppl. 01) 219-224
• 17 Shneerson C, Taskila T, Gale N et al. The effect of complementary and alternative medicine on the quality of life of cancer survivors: a systematic review and meta-analyses. Complement Ther Med 2013; 21: 417-429
• 18 Kreienberg R, Albert US, Follmann M et al. Interdisziplinäre S3-Leitlinie für die Diagnostik, Therapie und Nachsorge des Mammakarzinoms. Geburtshilfe Frauenheilkd 2013; 73: 556-583
• 19 Arbeitsgemeinschaft gynäkologische Onkologie e. V Kommission Mamma Hrsg. Diagnosis and treatment of patients with primary and metastatic breast cancer. München: W. Zuckschwerdt Verlag GmbH; 2013
• 20 Hüttner N, Hack CC, Hackl J et al. Klassische Naturheilverfahren nach Kneipp in der Gynäkologie und Geburtshilfe. Frauenheilkunde up2date 2014; 8: 92-111
• 21 Bokmand S, Flyger H. Acupuncture relieves menopausal discomfort in breast cancer patients: a prospective, double blinded, randomized study. Breast 2013; 22: 320-323
• 22 Mishra SI, Scherer RW, Snyder C et al. Exercise interventions on health-related quality of life for people with cancer during active treatment. Cochrane Database SystRev CD 008465 2012; 8
• 23 Andersen SR, Wurtzen H, Steding-Jessen M et al. Effect of mindfulness-based stress reduction on sleep quality: results of a randomized trial among Danish breast cancer patients. Acta Oncol 2013; 52: 336-344
• 24 Wurtzen H, Dalton SO, Elsass P et al. Mindfulness significantly reduces self-reported levels of anxiety and depression: results of a randomised controlled trial among 336 Danish women treated for stage I-III breast cancer. Eur J Cancer 2013; 49: 1365-1373
• 25 Cramer H, Rabsilber S, Lauche R et al. Yoga and meditation for menopausal symptoms in breast cancer survivors-A randomized controlled trial. Cancer [Epubaheadofprint] 2015;
• 26 Piet J, Wurtzen H, Zachariae R. The effect of mindfulness-based therapy on symptoms of anxiety and depression in adult cancer patients and survivors: a systematic review and meta-analysis. J ConsultClinPsychol 2012; 80: 1007-1020
• 27 Kiecolt-Glaser JK, Bennett JM, Andridge R et al. Yoga's impact on inflammation, mood, and fatigue in breast cancer survivors: a randomized controlled trial. J ClinOncol 2014; 32: 1040-1049
• 28 Chan CL, Wang CW, Ho RT et al. A systematic review of the effectiveness of qigong exercise in supportive cancer care. Support Care Cancer 2012; 20: 1121-1133
• 29 Bussing A, Raak C, Ostermann T. Quality of life and related dimensions in cancer patients treated with mistletoe extract (iscador): a meta-analysis. Evidence-based complementary and alternative medicine: Evid Based Complement. Alternat Med 2012; 2012: 219402-219402
• 30 Dusek JA, Benson H. Mind-body medicine: a model of the comparative clinical impact of the acute stress and relaxation responses. Minn Med 2009; 92: 47-50
• 31 Dobos G, Paul A Hrsg. Mind-Body-Medizin. Die moderne Ordnungstherapie in Theorie und Praxis. München: Elsevier; 2011
• 32 Pierce JP, Stefanick ML, Flatt SW et al. Greater survival after breast cancer in physically active women with high vegetable-fruit intake regardless of obesity. J ClinOncol 2007; 25: 2345-2351
• 33 Dobos GJ, Voiss P, Schwidde I et al. Integrative oncology for breast cancer patients: introduction of an expert-based model. BMC cancer 2012; 12: 539-539
• 34 Dobos G, Overhamm T, Bussing A et al. Integrating mindfulness in supportive cancer care: a cohort study on a mindfulness-based day care clinic for cancer survivors. Support Care Cancer [Epubaheadofprint] 2015;
• 35 Matchim Y, Armer JM, Stewart BR. Mindfulness-based stress reduction among breast cancer survivors: a literature review and discussion. Oncol Nurs Forum 2011; 38: 61-71
• 36 Shennan C, Payne S, Fenlon D. What is the evidence for the use of mindfulness-based interventions in cancer care? A review. Psychooncology 2011; 20: 681-697
• 37 Ott MJ, Norris RL, Bauer-Wu SM. Mindfulness meditation for oncology patients: a discussion and critical review. Integr Cancer Ther 2006; 5: 98-108
• 38 Smith JE, Richardson J, Hoffman C et al. Mindfulness-based stress reduction as supportive therapy in cancer care: systematic review. J Adv Nurs 2005; 52: 315-327
• 39 Cramer H, Lauche R, Paul A et al. Mindfulness-based stress reduction for breast cancer-a systematic review and meta-analysis. CurrOncol 2012; 19: 343-352
• 40 Bicego D, Brown K, Ruddick M et al. Effects of exercise on quality of life in women living with breast cancer: a systematic review. Breast J 2009; 15: 45-51
• 41 McNeely ML, Campbell KL, Rowe BH et al. Effects of exercise on breast cancer patients and survivors: a systematic review and meta-analysis. CMAJ 2006; 175: 34-41
• 42 Markes M, Brockow T, Resch KL. Exercise for women receiving adjuvant therapy for breast cancer. Cochrane Database SystRev CD 005001 2006;
• 43 Kim CJ, Kang DH, Park JW. A meta-analysis of aerobic exercise interventions for women with breast cancer. West J Nurs Res 2009; 31: 437-461
• 44 Cramp F, Daniel J. Exercise for the management of cancer-related fatigue in adults. Cochrane Database SystRev CD 006145 2008;
• 45 Kreienberg R, Albert US, Follmann M et al. InterdisciplinaryGoRlevel III guidelinesforthediagnosis, therapyand follow-up care ofbreastcancer: Interdisziplinäre S3-Leitlinie für die Diagnostik, Therapie und Nachsorge des Mammakarzinoms. Geburtshilfe Frauenheilkd 2013; 73: 556-583
• 46 Kommission Mamma der Arbeitsgemeinschaft Gynäkologische Onkologie e. V Hrsg. Diagnosis and treatment of patients with primary and metastatic breast cancer. München: W. Zuckschwerdt Verlag GmbH; 2013
• 47 Zainal NZ, Booth S, Huppert FA. The efficacy of mindfulness-based stress reduction on mental health of breast cancer patients: a meta-analysis. Psychooncology 2013; 22: 1457-1465
• 48 Lee A, Fan LT. Stimulation of the wrist acupuncture point P6 for preventing postoperative nausea and vomiting. Cochrane Database SystRev CD 003281 2009;
• 49 Ezzo J, Richardson M, Vickers A et al. Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting. Cochrane Database SystRev CD 002285 2006;
• 50 Posadzki P, Moon TW, Choi TY et al. Acupuncture for cancer-related fatigue: a systematic review of randomized clinical trials. Support Care Cancer 2013; 21: 2067-2073
• 51 Ryan JL, Heckler CE, Roscoe JA et al. Ginger (Zingiberofficinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients. Support Care Cancer 2012; 20: 1479-1489
• 52 Pommier P, Gomez F, Sunyach MP et al. Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J ClinOncol 2004; 22: 1447-1453
• 53 Mead GE, Morley W, Campbell P et al. Exercise for depression. Cochrane Database Syst Rev CD 004366 2008;
• 54 Cramer H, Lange S, Klose P et al. Can yoga improve fatigue in breast cancer patients? A systematicreview. Acta Oncol 2012; 51: 559-560
• 55 Ezzo JM, Richardson MA, Vickers A et al. Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting. Cochrane Database SystRev CD 002285 2006;
• 56 Zeng Y, Luo T, Finnegan-John J et al. Meta-Analysis of randomized controlled trials of acupuncture for cancer-related fatigue. Integr Cancer Ther 2013; 13: 193-200
• 57 Walker EM, Rodriguez AI, Kohn B et al. Acupuncture versus venlafaxine for the management of vasomotor symptoms in patients with hormone receptor-positive breast cancer: a randomized controlled trial. J ClinOncol 2010; 28: 634-640
• 58 Rostock M, Jaroslawski K, Guethlin C et al. Chemotherapy-induced peripheral neuropathy in cancer patients: a four-arm randomized trial on the effectiveness of electroacupuncture. EvidBasedComplement Alternat Med 2013; 2013: 349653-349653
• 59 Bao T, Cai L, Snyder C et al. Patient-reported outcomes in women with breast cancer enrolled in a dual-center, double-blind, randomized controlled trial assessing the effect of acupuncture in reducing aromatase inhibitor-induced musculoskeletal symptoms. Cancer 2014; 120: 381-389
• 60 Bao T, Cai L, Giles JT et al. A dual-center randomized controlled double blind trial assessing the effect of acupuncture in reducing musculoskeletal symptoms in breast cancer patients taking aromatase inhibitors. Breast Cancer Res Treat 2013; 138: 167-174
• 61 Goey AK, Mooiman KD, Beijnen JH et al. Relevance of in vitro and clinical data for predicting CYP3A4-mediated herb-drug interactions in cancer patients. Cancer TreatRev 2013; 39: 773-783
• 62 Unger M. Pharmakokinetische Arzneimittelinteraktionen zwischen Tumortherapeutika und Arzneimitteln der Komplementären Medizin: Mechanismen und klinische Relevanz. Forsch Komplementmed 2011; 18: 213-218
• 63 Cho YA, Lee W, Choi JS. Effects of curcumin on the pharmacokinetics of tamoxifen and its active metabolite, 4-hydroxytamoxifen, in rats: possible role of CYP3A4 and P-glycoprotein inhibition by curcumin. Pharmazie 2012; 67: 124-130
• 64 Alsanad SM, Williamson EM, Howard RL. Cancer patients at risk of herb/food supplement-drug interactions: a systematic review. Phytother Res 2014; 28: 1749-1755
• 65 Andersen MR, Sweet E, Lowe KA et al. Dangerous combinations: Ingestible CAM supplement use during chemotherapy in patients with ovarian cancer. J Altern Complement Med 2013; 19: 714-720
• 66 Goey AK, Meijerman I, Rosing H et al. The effect of St John's wort on the pharmacokinetics of docetaxel. ClinPharmacokinet 2014; 53: 103-110